Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment.

Current Cardiology Reviews
Vadim V GenkelIgor I Shaposhnik

Abstract

The article provides an overview of current views on the role of biomechanical forces in the pathogenesis of atherosclerosis. The importance of biomechanical forces in maintaining vascular homeostasis is considered. We provide descriptions of mechanosensing and mechanotransduction. The roles of wall shear stress and circumferential wall stress in the initiation, progression and destabilization of atherosclerotic plaque are described. The data on the possibilities of assessing biomechanical factors in clinical practice and the clinical significance of this approach are presented. The article concludes with a discussion on current therapeutic approaches based on the modulation of biomechanical forces.

References

Sep 13, 1969·Nature·C G CaroR C Schroter
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Joseph J BoyleMartin R Bennett
Jun 12, 2003·Journal of the American College of Cardiology·Piero O BonettiGregory W Barsness
Jun 8, 2004·Current Drug Targets. Cardiovascular & Haematological Disorders·David A Steinman
May 10, 2005·The Journal of Biological Chemistry·Kush M ParmarGuillermo García-Cardeña
Aug 23, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Guifu WuWilliam E Lawson
Jul 20, 2006·Journal of the Royal Society, Interface·Colin G CaroNick Watkins
Dec 13, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·H J T A M HuijbregtsF L Moll
Jun 9, 2007·Journal of Applied Physiology·Steven K NishiyamaRussell S Richardson
Sep 18, 2007·Expert Review of Cardiovascular Therapy·Ioannis PantosDemosthenes Katritsis
Mar 8, 2008·Medical & Biological Engineering & Computing·Robert S Reneman, Arnold P G Hoeks
Nov 26, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael E Widlansky
Mar 21, 2009·Journal of Applied Physiology·Henry Y ChenGhassan S Kassab
Apr 22, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Alina G van der GiessenFrank J H Gijsen
Sep 5, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Mustafa ZakkarPaul C Evans
Oct 8, 2009·Current Opinion in Cardiology·Konstantinos C KoskinasCharles L Feldman
Oct 17, 2009·Journal of Applied Physiology·Beth A ParkerJessica R Meendering
Dec 1, 2009·The International Journal of Cardiovascular Imaging·Alina G van der GiessenJolanda J Wentzel
Apr 20, 2010·Expert Review of Cardiovascular Therapy·Saurabh S DhawanHabib Samady
May 4, 2011·Current Opinion in Biotechnology·Andrew W Holle, Adam J Engler
Jun 4, 2011·VASA. Zeitschrift für Gefässkrankheiten·A Bondke PerssonI Buschmann
Jun 15, 2011·Physiology·Jaume PadillaM Harold Laughlin
Feb 2, 2012·Journal of Visualized Experiments : JoVE·Michael T KuhlmannMichael Schäfers
Apr 7, 2012·Journal of the American College of Cardiology·Konstantinos C KoskinasGeorge D Giannoglou
Jun 6, 2012·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Oberdan ParodiNenad Filipovic
Jun 12, 2012·Annals of Vascular Surgery·Peter A StonebridgeGraeme Houston
Jan 21, 2014·Cell Transplantation·Yi-Shiuan Liu, Oscar K Lee
Jan 30, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Joseph W WraggRoy Bicknell
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Peter A GalieChristopher S Chen
May 24, 2014·Biophysical Journal·Michael J MitchellMichael R King
Jul 11, 2014·Progress in Biophysics and Molecular Biology·Gregory R FedorchakJan Lammerding
Aug 29, 2014·DNA and Cell Biology·Xiaohong LiDangheng Wei
Sep 19, 2014·European Heart Journal·Brenda R KwakPaul C Evans
Oct 11, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun-ichi Abe, Bradford C Berk
Feb 11, 2015·Nature Reviews. Cardiology·Magnus Bäck, Göran K Hansson
Feb 13, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·George A DominguezDaniel A Hammer
Oct 16, 2015·Annals of Biomedical Engineering·Efstratios KokkalisJ Graeme Houston
Oct 20, 2015·Journal of Atherosclerosis and Thrombosis·Kyoung Im ChoJung Ho Heo
Jan 30, 2016·Nature Reviews. Cardiology·Adam J BrownMartin R Bennett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Clinical calcium
Kimiko Yamamoto, Joji Ando
Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Doroteia Silva, António Pais de Lacerda
Nihon rinsho. Japanese journal of clinical medicine
Takahiko NarukoMakiko Ueda
© 2021 Meta ULC. All rights reserved