Biomechanical, histological, and radiological effects of different phosphodiesterase inhibitors on femoral fracture healing in rats

Journal of Orthopaedic Surgery
Yasar Mahsut DincelYunus Ziya Arslan

Abstract

To investigate the biomechanical, histological, and radiological effects of sildenafil and pentoxifylline on femoral fracture healing in rats. Forty-eight Sprague-Dawley rats were divided into three groups equally according to the pharmacological agents to be investigated. Femoral shaft fractures were formed in the left side. Group 1 (control group), group 2, and group 3 were administered with saline, sildenafil, and pentoxifylline during the fracture healing process, respectively. Eight rats from each group were euthanized on days 15 and 30. X-ray images of the rats were taken after euthanasia for radiographical examination. Femur samples were subjected to histopathological and biomechanical (three-point bending) examinations. Radiologically, no difference between the Goldberg scores of the groups was found for day 15 ( p > 0.05), while higher Goldberg scores were obtained from group 2 than that of group 1 ( p > 0.05) and group 3 ( p < 0.05) for day 30. In the biomechanical analysis, higher mean breaking forces were found both for day 15 and day 30 from group 2 than those obtained from group 1 (for day 15 p > 0.05 and day 30 p > 0.05) and group 3 (for day 15 p < 0.05 and day 30 p < 0.01). Higher mean absorbed energy values wer...Continue Reading

References

May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M H HuoG E Friedlaender
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·V M GoldbergK G Heiple
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M HadjiargyrouC T Rubin
Jun 29, 2000·The Journal of Bone and Joint Surgery. British Volume·S A CorbettS P Hughes
Nov 3, 2001·The Journal of Allergy and Clinical Immunology·D M Essayan
Jan 4, 2003·Hypertension·Katsuya AmanoToshiji Iwasaka
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul OkunieffLynn H Gerber
Nov 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sylvie DelanianJean-Louis Lefaix
Jan 26, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jasmin LienauHermann J Bail
Aug 3, 2006·Nature Reviews. Drug Discovery·Hossein A GhofraniFriedrich Grimminger
Jun 23, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Annamalai SenthilkumarChristopher G Kevil
Jan 20, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tina HistingMichael D Menger
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Nora KahenasaIchiro Nishimura
May 23, 2013·Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery·Gökçen KerimoğluAtilla Çıtlak
Aug 31, 2013·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Aditya ChaubeyDavid Butler
Nov 22, 2014·Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery·Birhan OktaşNil Ustündağ
Apr 22, 2015·Drug Design, Development and Therapy·Yusuf AtalayMehmet Eroglu
Sep 22, 2015·Drug Design, Development and Therapy·Yusuf AtalayRezzan Guner
Oct 31, 2015·Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery·Güray ToğralM Fatih Ekşioğlu
Feb 13, 2016·Open Heart·Mark F McCartyJames J DiNicolantonio

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Citations

Aug 30, 2020·Annals of the New York Academy of Sciences·Se-Min KimMone Zaidi
Aug 29, 2020·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Mohsen MalekiGorjiSeyyed Mohammad Razavi
Jun 10, 2019·Clinical Hemorheology and Microcirculation·Rebecca RotheJens Pietzsch
Dec 4, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·André L de Campos PessoaJorge J de Carvalho
Mar 15, 2021·Archives of Dermatological Research·Rafael A C SouzaThaís R Sudbrack

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Methods Mentioned

BETA
X-ray
light microscopy

Software Mentioned

SPSS Statistics
Bluehill
SPSS

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