Biomechanical model for computing deformations for whole-body image registration: A meshless approach

International Journal for Numerical Methods in Biomedical Engineering
Mao LiAdam Wittek

Abstract

Patient-specific biomechanical models have been advocated as a tool for predicting deformations of soft body organs/tissue for medical image registration (aligning two sets of images) when differences between the images are large. However, complex and irregular geometry of the body organs makes generation of patient-specific biomechanical models very time-consuming. Meshless discretisation has been proposed to solve this challenge. However, applications so far have been limited to 2D models and computing single organ deformations. In this study, 3D comprehensive patient-specific nonlinear biomechanical models implemented using meshless Total Lagrangian explicit dynamics algorithms are applied to predict a 3D deformation field for whole-body image registration. Unlike a conventional approach that requires dividing (segmenting) the image into non-overlapping constituents representing different organs/tissues, the mechanical properties are assigned using the fuzzy c-means algorithm without the image segmentation. Verification indicates that the deformations predicted using the proposed meshless approach are for practical purposes the same as those obtained using the previously validated finite element models. To quantitatively eva...Continue Reading

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Citations

Aug 20, 2016·Biomechanics and Modeling in Mechanobiology·M K RauschJ D Humphrey
Oct 15, 2021·International Journal for Numerical Methods in Biomedical Engineering·Yue YuKarol Miller

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