Biomechanical profiling of Caenorhabditis elegans motility.

Genetics
P KrajacicT Lamitina

Abstract

Caenorhabditis elegans locomotion is a stereotyped behavior that is ideal for genetic analysis. We integrated video microscopy, image analysis algorithms, and fluid mechanics principles to describe the C. elegans swim gait. Quantification of body shapes and external hydrodynamics and model-based estimates of biomechanics reveal that mutants affecting similar biological processes exhibit related patterns of biomechanical differences. Therefore, biomechanical profiling could be useful for predicting the function of previously unstudied motility genes.

References

May 1, 1974·Genetics·S Brenner
Oct 28, 1998·Journal of Physiology, Paris·M ArpagausJ P Toutant
Sep 15, 2001·Science·S K KimG S Davidson
Oct 3, 2001·International Review of Cytology·D CombesM Arpagaus
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·J A Sethian
Mar 5, 2003·BioTechniques·A I SaeedJ Quackenbush
Aug 28, 2003·Médecine sciences : M/S·Christelle Gally, Jean-Louis Bessereau
Jan 1, 1955·Zeitschrift für Zellforschung und mikroskopische Anatomie·B A AFZELIUS
Jul 29, 2004·The Journal of Biological Chemistry·Emmanuel CulettoDavid B Sattelle
Nov 23, 2007·Nature·Michael PetrascheckLinda B Buck
Apr 29, 2008·IEEE Transactions on Bio-medical Engineering·Gabriel TsechpenakisMonica Driscoll
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan T Pierce-ShimomuraSteven L McIntire
Jul 22, 2009·BMC Neuroscience·Steven D Buckingham, David B Sattelle
Feb 18, 2010·Biophysical Journal·J SznitmanP E Arratia
Nov 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Christopher Fang-YenAravinthan D T Samuel
Jun 7, 2011·Nature Methods·Nicholas A SwierczekRex A Kerr

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Citations

Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·André E X BrownWilliam R Schafer
Jul 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica E TanisTodd Lamitina
Apr 15, 2014·Methods : a Companion to Methods in Enzymology·Scott Alexander KeithArjumand Ghazi
Jul 23, 2014·IEEE Transactions on Bio-medical Engineering·Ayala GreenblumJosue Sznitman
May 27, 2015·Lab on a Chip·Jinzhou YuanHaim H Bau
Sep 2, 2016·Journal of the Royal Society, Interface·Alex Gomez-MarinAndré E X Brown
Oct 12, 2016·Scientific Reports·Peter B WinterLuis A N Amaral
Feb 20, 2019·Nature Communications·Takuma SugiKen H Nagai
Feb 14, 2019·Proceedings of the National Academy of Sciences of the United States of America·K J HughesA G Vidal-Gadea
May 15, 2020·Combinatorial Chemistry & High Throughput Screening·Pradeep HanumanthappaAparna H Sosalegowda
Jun 3, 2021·International Journal of Molecular Sciences·Rebecca A EllwoodNathaniel J Szewczyk
Jul 2, 2021·Toxicology Reports·Fernando CalahorroVincent O'Connor
Sep 11, 2021·PLoS Computational Biology·Erik SaberskiGeorge Sugihara

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