Biomechanical Properties and Microstructural Analysis of the Human Nonaneurysmal Aorta as a Function of Age, Gender and Location: An Autopsy Study

Journal of Vascular Research
Otavio Henrique NinomiyaErasmo Simao da Silva

Abstract

The biomechanical failure properties and histological composition of the human nonaneurysmal aorta were studied. Twenty-six human aortas were harvested from fresh cadavers at autopsy. A total of 153 circumferentially oriented strips were obtained from the aortas for biomechanical and histological studies. The failure load (6.18 ± 2.03 vs. 4.85 ± 2.04 N; p = 0.001), failure tension (19.88 ± 9.05 vs. 14.53 ± 7 N/cm; p = 0.001), failure strain (0.66 ± 0.31 vs. 0.49 ± 0.25; p = 0.003) and amount of elastic fibers (19.39 ± 15.57 vs. 14.06 ± 9.5%; p = 0.011) were all significantly higher for the thoracic than the abdominal aorta. There was a significant negative correlation between age and failure load (R = -0.35; p < 0.0001), failure stress (R = -0.63; p < 0.0001), failure tension (R = -0.52; p < 0.0001) and failure strain (R = -0.8; p < 0.0001). Male aortas had a higher failure load and failure tension than female aortas. The thoracic aorta has a higher strength and elasticity than the abdominal aorta. The elderly have weaker and stiffer aortas than the young. Male aortas are stronger than female aortas.

Citations

Jan 6, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Peggy RobinetJonathan D Smith
Apr 3, 2019·International Angiology : a Journal of the International Union of Angiology·Lara R DiasArmando Mansilha
Dec 12, 2020·Data in Brief·Vivian Carla GomesErasmo Simão da Silva
Jan 2, 2021·Annals of Vascular Surgery·Vivian Carla GomesErasmo Simão da Silva
Apr 16, 2021·Data in Brief·Vivian Carla GomesErasmo Simão da Silva
Sep 7, 2020·Annals of Vascular Surgery·Vivian Carla GomesErasmo Simão da Silva
Aug 20, 2021·Annals of Vascular Surgery·Vivian Carla GomesErasmo Simão da Silva

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