Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures

Annals of the Rheumatic Diseases
Fabian StemmlerArnd Kleyer

Abstract

Bone loss is a well-established consequence of rheumatoid arthritis (RA). To date, bone disease in RA is exclusively characterised by bone density measurements, while the functional properties of bone in RA are undefined. This study aimed to define the impact of RA on the functional properties of bone, such as failure load and stiffness. Micro-finite element analysis (µFEA) was carried out to measure failure load and stiffness of bone based on high-resolution peripheral quantitative CT data from the distal radius of anti-citrullinated protein antibody (ACPA)-positive RA (RA+), ACPA-negative RA (RA-) and healthy controls (HC). In addition, total, trabecular and cortical bone densities as well as microstructural parameters of bone were recorded. Correlations and multivariate models were used to determine the role of demographic, disease-specific and structural data of bone strength as well as its relation to prevalent fractures. 276 individuals were analysed. Failure load and stiffness (both P<0.001) of bone were decreased in RA+, but not RA-, compared with HC. Lower bone strength affected both female and male patients with RA+, was related to longer disease duration and significantly (stiffness P=0.020; failure load P=0.012) ass...Continue Reading

References

Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Stephanie BoutroyPierre D Delmas
Dec 16, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaL Joseph Melton
Dec 22, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduPierre D Delmas
Jun 2, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonSundeep Khosla
Nov 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stephanie BoutroyPierre D Delmas
Jan 20, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N DalzellJ Reeve
Jul 2, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heather M MacdonaldSteven K Boyd
May 5, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicolas VilayphiouRoland Chapurlat
Dec 14, 2011·The New England Journal of Medicine·Iain B McInnes, Georg Schett
Apr 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stinus HansenClaus H Gravholt
Apr 17, 2012·The Journal of Clinical Investigation·Ulrike HarreGeorg Schett
Sep 26, 2012·Nature Reviews. Rheumatology·Georg Schett, Ellen Gravallese
Oct 24, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tracy Y ZhuLai-Shan Tam
Oct 27, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A TrombettiR Rizzoli
Dec 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Emily M SteinJohn P Bilezikian
Apr 5, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth A P M RommeJoop P W van den Bergh
Apr 1, 2015·Nature Communications·Ulrike HarreGeorg Schett
Apr 2, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roland KocijanGeorg Schett
May 10, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R KocijanH Resch
Jun 23, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vikram V ShanbhogueKim Brixen
Feb 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vikram V ShanbhogueStinus Hansen
May 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lauren A BurtSteven K Boyd
Oct 28, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David SimonGeorg Schett
Apr 21, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cecilia EngdahlGeorg Schett

❮ Previous
Next ❯

Citations

Feb 20, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bettina GrötschAline Bozec
Nov 27, 2019·International Journal of Molecular Sciences·Giovanni AdamiDavide Gatti
May 13, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David SimonArnd Kleyer
Jul 2, 2020·Expert Opinion on Pharmacotherapy·Hennie G RatermanWillem F Lems
May 28, 2019·Current Rheumatology Reports·Giovanni Adami, Kenneth G Saag
Jan 19, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N GuañabensUNKNOWN OsteoResSer Working Group of the Spanish Society of Rheumatology

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

FAIM
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.