Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback

Journal of Biomechanical Engineering
Emily R PfeifferAndrew D McCulloch

Abstract

Cardiac mechanical contraction is triggered by electrical activation via an intracellular calcium-dependent process known as excitation-contraction coupling. Dysregulation of cardiac myocyte intracellular calcium handling is a common feature of heart failure. At the organ scale, electrical dyssynchrony leads to mechanical alterations and exacerbates pump dysfunction in heart failure. A reverse coupling between cardiac mechanics and electrophysiology is also well established. It is commonly referred as cardiac mechanoelectric feedback and thought to be an important contributor to the increased risk of arrhythmia during pathological conditions that alter regional cardiac wall mechanics, including heart failure. At the cellular scale, most investigations of myocyte mechanoelectric feedback have focused on the roles of stretch-activated ion channels, though mechanisms that are independent of ionic currents have also been described. Here we review excitation-contraction coupling and mechanoelectric feedback at the cellular and organ scales, and we identify the need for new multicellular tissue-scale model systems and experiments that can help us to obtain a better understanding of how interactions between electrophysiological and me...Continue Reading

References

Jan 1, 1992·Experimental Physiology·P KohlT Streubel
May 1, 1989·Pflügers Archiv : European journal of physiology·M B RookB de Jonge
Aug 1, 1988·Journal of Molecular and Cellular Cardiology·P A Hofmann, F Fuchs
Apr 1, 1987·Canadian Journal of Physiology and Pharmacology·H E ter KeursP P de Tombe
Feb 1, 1972·Circulation Research·R J MyerburgH Gelband
Nov 1, 1969·Circulation Research·J V TybergE H Sonnenblick
Jun 1, 1970·Circulation·D DurrerR C Arzbaecher
Apr 1, 1980·Circulation·C R WyndhamK M Rosen
May 1, 1984·Circulation·J A VassalloM E Josephson
Jun 1, 1980·The Journal of General Physiology·D E ClaphamR L DeHaan
Jan 1, 1994·Annals of Biomedical Engineering·K A BarbeeL E Thibault
Apr 1, 1993·Pflügers Archiv : European journal of physiology·T DelhaasR S Reneman
Sep 1, 1996·Journal of Cardiovascular Electrophysiology·T Satoh, D P Zipes
Jun 1, 1997·Journal of Molecular and Cellular Cardiology·H Hu, F Sachs
Jul 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T EschenhagenE L Elson
Mar 10, 1999·Progress in Biophysics and Molecular Biology·P KohlD Noble
Oct 20, 1999·Journal of Molecular and Cellular Cardiology·A A LeeF J Villarreal
Mar 23, 2000·Cardiovascular Research·I KiselevaM J Lab
Apr 4, 2000·Physiological Reviews·A M GordonM Regnier
Apr 14, 2000·Circulation Research·J E SaffitzK A Yamada
Aug 19, 2000·Circulation Research·J ZhuangA G Kléber
Dec 16, 2000·Journal of Cardiovascular Pharmacology·L EckardtW Haverkamp
Feb 28, 2001·The Journal of Membrane Biology·C E Morris, U Homann
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Bradley T WymanElliot R McVeigh
Jan 15, 2002·Journal of the American College of Cardiology·Christophe Leclercq, David A Kass
Jan 24, 2002·Nature·Donald M Bers
Feb 15, 2002·Journal of Cardiovascular Electrophysiology·Steven M Pogwizd, Donald M Bers
Mar 29, 2002·Journal of Biomedical Materials Research·Todd C McDevittPatrick S Stayton
May 7, 2002·Pacing and Clinical Electrophysiology : PACE·Frits W Prinzen, Maaike Peschar

❮ Previous
Next ❯

Citations

Feb 2, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kristina RücklováJan Janoušek
Aug 15, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Malcolm C FinlayPeter Taggart
Nov 26, 2015·Cardiac Electrophysiology Clinics·Jonathan A Kirk, David A Kass
Oct 21, 2016·Clinical and Experimental Pharmacology & Physiology·Irene Del CantoFrancisco J Chorro
Apr 15, 2018·Circulation. Arrhythmia and Electrophysiology·Sally-Ann B ClurBettina F Cuneo
Jan 12, 2019·Proteomics. Clinical Applications·Zhen-Yu ZhangJan A Staessen
May 1, 2015·Biomedical Engineering Online·Alejandro Lopez-PerezJose M Ferrero
Jun 22, 2019·Journal of Biomedical Optics·Yunze YangNongjian Tao
Jun 17, 2018·Physical Review. E·Azzam HazimStevan Dubljevic
May 24, 2018·Pediatric Cardiology·Arja Suzanne VinkSally-Ann B Clur
Apr 8, 2019·Biomedical Microdevices·Long V LeTejal A Desai
Feb 20, 2020·The Journal of Physiological Sciences : JPS·Nathalie A Balakina-VikulovaLeonid B Katsnelson
Jan 3, 2020·Science Translational Medicine·Sujitha ThavapalachandranJames J H Chong
Dec 29, 2020·Frontiers in Physiology·Viviane Timmermann, Andrew D McCulloch
Aug 28, 2020·Progress in Biophysics and Molecular Biology·Anastasia BazhutinaLeonid B Katsnelson
Feb 9, 2021·Bioactive Materials·Keshav Narayan AlagarsamySanjiv Dhingra
Apr 16, 2021·Pflügers Archiv : European journal of physiology·Oisín KingCesare M Terracciano
Jun 12, 2021·Medicinal Research Reviews·Hanne BeliënAnnelies Bronckaers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Biomechanics

Biomechanics examines the generation of internal forces within the body and investigates the effects and control of forces that act on or are produced on tissues. Here are the latest discoveries.

Related Papers

Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova
O E Solov'evaV S Markhasin
Progress in Biophysics and Molecular Biology
Yibing ZhangLeslie Tung
Journal of Cardiovascular Pharmacology
M J Lab, J Dean
Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Edmund J CrampinClive H Orchard
© 2021 Meta ULC. All rights reserved