Biomechanics of the chick embryonic heart outflow tract at HH18 using 4D optical coherence tomography imaging and computational modeling

PloS One
Aiping LiuSandra Rugonyi


During developmental stages, biomechanical stimuli on cardiac cells modulate genetic programs, and deviations from normal stimuli can lead to cardiac defects. Therefore, it is important to characterize normal cardiac biomechanical stimuli during early developmental stages. Using the chicken embryo model of cardiac development, we focused on characterizing biomechanical stimuli on the Hamburger-Hamilton (HH) 18 chick cardiac outflow tract (OFT), the distal portion of the heart from which a large portion of defects observed in humans originate. To characterize biomechanical stimuli in the OFT, we used a combination of in vivo optical coherence tomography (OCT) imaging, physiological measurements and computational fluid dynamics (CFD) modeling. We found that, at HH18, the proximal portion of the OFT wall undergoes larger circumferential strains than its distal portion, while the distal portion of the OFT wall undergoes larger wall stresses. Maximal wall shear stresses were generally found on the surface of endocardial cushions, which are protrusions of extracellular matrix onto the OFT lumen that later during development give rise to cardiac septa and valves. The non-uniform spatial and temporal distributions of stresses and strai...Continue Reading


Jan 1, 1977·The American Journal of Anatomy·R R MarkwaldF J Manasek
Dec 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V Hamburger, H L Hamilton
Jan 1, 1991·Circulation Research·B B KellerE B Clark
Dec 1, 1989·Circulation Research·N Hu, E B Clark
Oct 1, 1989·The Anatomical Record·J M Icardo
Mar 1, 1986·The American Journal of Physiology·E B ClarkR Tomanek
Nov 1, 1985·Journal of Biomechanical Engineering·M J Levesque, R M Nerem
Jun 1, 1970·The Journal of Experimental Zoology·P C Greenfield, E J Boell
May 1, 1994·Journal of Biomechanical Engineering·M YangE B Clark
Feb 1, 1993·Circulation Research·L A TaberB B Keller
Aug 1, 1995·Journal of Biomechanical Engineering·I E Lin, L A Taber
Jul 1, 1997·The Anatomical Record·D SedmeraE B Clark
Oct 24, 1998·Progress in Biophysics and Molecular Biology·J H Omens
Mar 7, 2001·In Vitro Cellular & Developmental Biology. Animal·C E MillerP R Chess
Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·A B FisherR M Nerem
Oct 12, 2001·The Anatomical Record·S R QayyumM K Richardson
Jan 11, 2002·Journal of Biomechanical Engineering·L A Taber, J D Humphrey
May 29, 2003·Birth Defects Research. Part C, Embryo Today : Reviews·Florence RothenbergMichiko Watanabe
Feb 1, 1955·The American Journal of Physiology·P M JOHNSTON
Nov 5, 2003·Nature Biotechnology·James G Fujimoto
Apr 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Thomas Bartman, Jay Hove
May 18, 2005·Journal of Biomechanics·Peter VennemannBeerend P Hierck
Jun 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brad J Martinsen
Sep 8, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kim Van der HeidenRobert E Poelmann
Aug 28, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Benjamen A FilasLarry A Taber
Jan 30, 2008·Medical & Biological Engineering & Computing·Robert E PoelmannBeerend P Hierck
Mar 12, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jörg MännerT Mesud Yelbuz
Apr 30, 2009·Journal of the Royal Society, Interface·C PoelmaJ Westerweel
May 7, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brooke J DamonRobert P Thompson
May 13, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A M OosterbaanE A P Steegers
Jan 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Barbara GaritaKersti K Linask
May 4, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David Sedmera, Robert P Thompson
May 17, 2011·Computers & Structures·Aiping LiuSandra Rugonyi

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