Biomechanics of the human uterus

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Kristin M Myers, David Elad

Abstract

The appropriate biomechanical function of the uterus is required for the execution of human reproduction. These functions range from aiding the transport of the embryo to the implantation site, to remodeling its tissue walls to host the placenta, to protecting the fetus during gestation, to contracting forcefully for a safe parturition and postpartum, to remodeling back to its nonpregnant condition to renew the cycle of menstruation. To serve these remarkably diverse functions, the uterus is optimally geared with evolving and contractile muscle and tissue layers that are cued by chemical, hormonal, electrical, and mechanical signals. The relationship between these highly active biological signaling mechanisms and uterine biomechanical function is not completely understood for normal reproductive processes and pathological conditions such as adenomyosis, endometriosis, infertility and preterm labor. Animal studies have illuminated the rich structural function of the uterus, particularly in pregnancy. In humans, medical imaging techniques in ultrasound and magnetic resonance have been combined with computational engineering techniques to characterize the uterus in vivo, and advanced experimental techniques have explored uterine f...Continue Reading

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Citations

Feb 7, 2020·Physiology·David EladDan Grisaru
Jul 3, 2019·Interface Focus·Michele J Grimm
Jun 18, 2020·APL Bioengineering·David EladDan Grisaru
Jul 3, 2019·Interface Focus·Ying ZhangDavid Elad
Nov 6, 2020·Biomedical Optics Express·James P McLeanChristine P Hendon
Apr 22, 2021·Annals of Biomedical Engineering·Shuyang FangKristin M Myers

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