Biomedical Potential of Ultrafine Ag Nanoparticles Coated on Poly (Gamma-Glutamic Acid) Hydrogel with Special Reference to Wound Healing

Nanomaterials
Yu WangPeng Yu

Abstract

In wound care management, the prevention of wound infection and the retention of an appropriate level of moisture are two major challenges. Therefore, designing an excellent antibacterial hydrogel with a suitable water-adsorbing capacity is very important to improve the development of wound dressings. In this paper, a novel silver nanoparticles/poly (gamma-glutamic acid) (γ-PGA) composite dressing was prepared for biomedical applications. The promoted wound-healing ability of the hydrogels were systematically evaluated with the aim of attaining a novel and effective wound dressing. A diffusion study showed that hydrogels can continuously release antibacterial factors (Ag). Hydrogels contain a high percentage of water, providing an ideal moist environment for tissue regeneration, while also preventing contraction of the wound. Moreover, an in vivo, wound-healing model evaluation of artificial wounds in mice indicated that silver/γ-PGA hydrogels could significantly promote wound healing. Histological examination revealed that hydrogels can successfully help to reconstruct intact epidermis and collagen deposition during 14 days of impaired wound healing. Overall, this research could shed new light on the design of anti...Continue Reading

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Citations

Jun 11, 2019·Frontiers in Bioengineering and Biotechnology·Milad Fathi-AchacheloueiNihal Engin Vrana
Feb 6, 2020·Frontiers in Microbiology·María Paulina RomeroNatalia Mayumi Inada
Oct 19, 2019·IET Nanobiotechnology·Debalina BhattacharyaMainak Mukhopadhyay

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Methods Mentioned

BETA
biopsies

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