Nov 9, 2017

Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease

Frontiers in Molecular Neuroscience
Yong LiHong Jiang


Biometal dyshomeostasis and toxic metal accumulation are common features in many neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease, and Huntington's disease. The neurotoxic effects of metal imbalance are generally associated with reduced enzymatic activities, elevated protein aggregation and oxidative stress in the central nervous system, in which a cascade of events lead to cell death and neurodegeneration. Although the links between biometal imbalance and neurodegenerative disorders remain elusive, a major class of endogenous proteins involved in metal transport has been receiving increasing attention over recent decades. The abnormal expression of these proteins has been linked to biometal imbalance and to the pathogenesis of AD. Here, we present a brief overview of the physiological roles of biometals including iron, zinc, copper, manganese, magnesium and calcium, and provide a detailed description of their transporters and their synergistic involvement in the development of AD. In addition, we also review the published data relating to neurotoxic metals in AD, including aluminum, lead, cadmium, and mercury.

  • References211
  • Citations5
  • References211
  • Citations5

Mentioned in this Paper

Pathogenic Aspects
Calcium [EPC]
Magnesium Measurement
Aluminum Measurement
Huntington's Disease Pathway

Related Feeds

Astrocytes and Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Related Papers

Metallomics : Integrated Biometal Science
David J BondaMark A Smith
The International Journal of Neuroscience
Atish PrakashAbu Bakar Abdul Majeed
Chemico-biological Interactions
Susana Rivera-MancíaSergio Montes
Trends in Pharmacological Sciences
Paolo ZattaStefano L Sensi
© 2020 Meta ULC. All rights reserved