Biomimetic and nanostructured hybrid bioactive glass

Biomaterials
Xianfeng ZhouWeilong Zhao

Abstract

Inspired by nature's toughening mechanisms, we designed a new polyhedral oligomeric silsesquioxane (POSS)-derived hybrid glass (PHG) that has covalent interactions on the molecular scale between the inorganic POSS cage and organic phase. These features allow "elastic deformation" of the inorganic POSS cage in limited scale. The final product is a bulk hybrid material with toughness (3.56 ± 0.25 MPa·m(1/2)) similar to natural bone (2.4-5.3 MPa·m(1/2)). PHG exhibited excellent bioactivity by promoting the formation of plate-like hydroxyapatite on its surface in simulated body fluid and showed good cell adhesion. PHG also can be a platform to guide adipose tissue-derived mesenchymal stem cells differentiation and mineralization. The key structural features of this material can be used to guide the design of bio-inspired composites with unique toughness, which would be of great benefit to hard tissue engineering.

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Citations

Sep 28, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Chang YeVijay K Vasudevan
Dec 15, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ruixia ZhangChang Ye
Aug 8, 2021·International Journal of Molecular Sciences·Juri SarutaTakahiro Ogawa
Jul 30, 2019·Biomacromolecules·Nana LuZhibo Li
Feb 23, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Chen LingNita Sahai

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