PMID: 16646490May 2, 2006Paper

Biomimetic approach to biomembrane models studies: medium influence on the interaction kinetics of some phenylurea derivatives herbicides

Environmental Science & Technology
Vito LibrandoFrancesco Castelli

Abstract

The ability of herbicides to interact with cell membranes outer lipid layer and subsequently to penetrate inside cells can be a prerequisite for exhibiting a toxic activity for both the directly exposed workers and the end consumers as the herbicides are present in the soil and water. The effect exerted by fenuron, chlorotoluron, metobromuron, monolinuron, and chlorbromuron, five structurally similar phenylurea herbicides, on the thermotropic behavior of model membranes, represented by dimyristoylphosphatidylcholine (DMPC) vesicles, was investigated by differential scanning calorimetry. The examined compounds, when dispersed in liposomes during their preparation, exerted a different action on the gel-to-liquid crystal phase transition of DMPC multilamellar vesicles. The ability of phenylurea herbicides, as a finely powdered solid, to migrate through an aqueous medium and interact with biomembrane models was also studied. This transfer process was compared with these compounds intermembrane transfer from herbicide-loaded liposomes to empty ones. These processes can mimic absorption kinetics mediated by hydrophilic or lipophilic media. Different rate and entity of interaction occurred between model membranes and solid phenylurea ...Continue Reading

References

Mar 1, 1991·Chemistry and Physics of Lipids·J R Silvius
Oct 1, 1987·Environmental Health Perspectives·J K HasemanE E McConnell
Mar 1, 1994·Free Radical Biology & Medicine·T KanekoM Matsuo
Jul 9, 2002·Environmental Science & Technology·Francesco CastelliMaria Grazia Sarpietro
Jun 1, 2003·Environmental Toxicology and Pharmacology·Vito LibrandoFrancesco Castelli

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Citations

May 2, 2015·Environmental Toxicology and Pharmacology·Vito LibrandoMaria Grazia Sarpietro

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