Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity

Drug Delivery
Kazuaki TaguchiToru Maruyama

Abstract

Macrophages play a central role in various inflammatory disorders and are broadly divided into two subpopulations, M1 and M2 macrophage. In the healing process in acute inflammatory disorders, shifting the production of M1 macrophages to M2 macrophages is desirable, because M1 macrophages secrete pro-inflammatory cytokines, whilst the M2 variety secrete anti-inflammatory cytokines. Previous findings indicate that when macrophages are treated with carbon monoxide (CO), the secretion of anti-inflammatory cytokine is increased and the expression of pro-inflammatory cytokines is inhibited, indicating that CO may have a potential to modulate the production of macrophages toward the M2-like phenotype. In this study, we examined the issue of whether CO targeting macrophages using a nanotechnology-based CO donor, namely CO-bound hemoglobin vesicles (CO-HbV), modulates their polarization and show therapeutic effects against inflammatory disorders. The results showed that the CO-HbV treatment polarized a macrophage cell line toward an M2-like phenotype. Furthermore, in an in vivo study using acute pancreatitis model mice as a model of an inflammatory disease, a CO-HbV treatment also tended to polarize macrophages toward an M2-like phenot...Continue Reading

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Citations

Nov 14, 2018·Current Medicinal Chemistry·Kazuaki TaguchiMasaki Otagiri
Nov 2, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuaki Taguchi
Feb 6, 2020·The Journal of Pharmacy and Pharmacology·Vaishnavi SundarTamizhselvi Ramasamy
Feb 6, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuaki TaguchiMasaki Otagiri
Oct 30, 2020·Drug Delivery·Xue JiangLongfa Kou
Jan 28, 2022·Artificial Cells, Nanomedicine, and Biotechnology·Chie Okuda, Hiromi Sakai

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Methods Mentioned

BETA
ELISA
PCR

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