Biomimetic engineering of a generic cell-on-membrane architecture by microfluidic engraving for on-chip bioassays

Langmuir : the ACS Journal of Surfaces and Colloids
Sang-Wook LeeSin-Doo Lee

Abstract

We develop a biomimetic cell-on-membrane architecture in close-volume format which allows the interfacial biocompatibility and the reagent delivery capability for on-chip bioassays. The key concept lies in the microfluidic engraving of lipid membranes together with biological cells on a supported substrate with topographic patterns. The simultaneous engraving process of a different class of fluids is promoted by the front propagation of an air-water interface inside a flow-cell. This highly parallel, microfluidic cell-on-membrane approach opens a door to the natural biocompatibility in mimicking cellular stimuli-response behavior essential for diverse on-chip bioassays that can be precisely controlled in the spatial and temporal manner.

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Citations

Aug 2, 2015·Chemistry and Physics of Lipids·C Patrick Collier
Aug 12, 2017·Biomicrofluidics·S Oyola-ReynosoM M Thuo

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