Biomimetic Intraneural Sensory Feedback Enhances Sensation Naturalness, Tactile Sensitivity, and Manual Dexterity in a Bidirectional Prosthesis

Neuron
Giacomo ValleSilvestro Micera

Abstract

Peripheral intraneural stimulation can provide tactile information to amputees. However, efforts are still necessary to identify encoding strategy eliciting percepts that are felt as both natural and effective for prosthesis control. Here we compared the naturalness and efficacy of different encoding strategies to deliver neural stimulation to trans-radial amputees implanted with intraneural electrodes. Biomimetic frequency modulation was perceived as more natural, while amplitude modulation enabled better performance in tasks requiring fine identification of the applied force. Notably, the optimal combination of naturalness and sensitivity of the tactile feedback can be achieved with "hybrid" encoding strategies based on simultaneous biomimetic frequency and amplitude neuromodulation. These strategies improved the gross manual dexterity of the subjects during functional task while maintaining high levels of manual accuracy. They also improved prosthesis embodiment, reducing abnormal phantom limb perceptions ("telescoping effect"). Hybrid strategies are able to provide highly sensitive and natural percepts and should be preferred. VIDEO ABSTRACT.

Citations

Nov 27, 2018·Annals of Neurology·Francesco M PetriniSilvestro Micera
Nov 26, 2019·Advanced Healthcare Materials·Annarita Cutrone, Silvestro Micera
Oct 4, 2019·Science Translational Medicine·Francesco Maria PetriniStanisa Raspopovic
Mar 25, 2020·Journal of Neural Engineering·Marina CracchioloSilvestro Micera
Jun 9, 2020·PLoS Biology·Roni O Maimon Mor, Tamar R Makin
Jul 11, 2020·Journal of Neural Engineering·Emanuele FormentoSilvestro Micera
Sep 11, 2019·Nature Medicine·Francesco Maria PetriniStanisa Raspopovic
Mar 17, 2020·EFORT Open Reviews·Marko BumbaširevićStanisa Raspopovic
May 28, 2020·Frontiers in Neurorobotics·Stacy T Lindau, Sliman J Bensmaia
Jun 2, 2020·Frontiers in Neuroscience·Giovanni Di PinoAngelo Maravita
Aug 30, 2020·Journal of Neuroengineering and Rehabilitation·Leonardo CappelloChristian Cipriani
Nov 30, 2018·Wiley Interdisciplinary Reviews. Cognitive Science·Philipp BeckerleBigna Lenggenhager
Sep 10, 2019·Frontiers in Neuroscience·Ivana CuberovicEmily L Graczyk
Feb 23, 2020·Journal of Neuroengineering and Rehabilitation·Marek ZelechowskiStanisa Raspopovic
Apr 11, 2020·Frontiers in Neuroscience·Ahmed W ShehataJacqueline S Hebert
Feb 23, 2020·Nature Biomedical Engineering·Max Ortiz-Catalan
Aug 15, 2020·Frontiers in Neurorobotics·Alexandra Middleton, Max Ortiz-Catalan
Apr 23, 2020·Frontiers in Bioengineering and Biotechnology·Giacomo ValleSilvestro Micera
Jul 14, 2020·Frontiers in Neuroscience·Jonathon W Sensinger, Strahinja Dosen
Nov 7, 2019·Journal of Medical Internet Research·Giacomo Valle
Dec 12, 2019·Journal of Neuroengineering and Rehabilitation·Meike Annika WilkeStrahinja Dosen
Dec 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Thierri CallierSliman J Bensmaia
Oct 21, 2020·Journal of Neural Engineering·Luke E OsbornNitish V Thakor
Nov 25, 2020·Nature Biomedical Engineering·Sliman J BensmaiaSilvestro Micera
Dec 3, 2020·APL Bioengineering·Arianna Menciassi, Veronica Iacovacci
Jan 9, 2021·Current Biology : CB·Greta PreatoniStanisa Raspopovic
Feb 20, 2019·Science Robotics·Edoardo D'AnnaSilvestro Micera
Jan 28, 2021·Frontiers in Robotics and AI·Alexander ToetJan B F van Erp
Feb 27, 2021·Journal of Neuroengineering and Rehabilitation·Michael D PaskettGregory A Clark

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.