Biomimetic nanoparticle technology for cardiovascular disease detection and treatment

Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy
Joon Ho ParkLiangfang Zhang

Abstract

Cardiovascular disease (CVD), which encompasses a number of conditions that can affect the heart and blood vessels, presents a major challenge for modern-day healthcare. Nearly one in three people has some form of CVD, with many suffering from multiple or intertwined conditions that can ultimately lead to traumatic events such as a heart attack or stroke. While the knowledge obtained in the past century regarding the cardiovascular system has paved the way for the development of life-prolonging drugs and treatment modalities, CVD remains one of the leading causes of death in developed countries. More recently, researchers have explored the application of nanotechnology to improve upon current clinical paradigms for the management of CVD. Nanoscale delivery systems have many advantages, including the ability to target diseased sites, improve drug bioavailability, and carry various functional payloads. In this review, we cover the different ways in which nanoparticle technology can be applied towards CVD diagnostics and treatments. The development of novel biomimetic platforms with enhanced functionalities is discussed in detail.

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Citations

Jul 18, 2020·Nanomedicine·Guoyu YangJianxiang Zhang
Jul 7, 2020·Frontiers in Bioengineering and Biotechnology·Manuela SushnithaFrancesca Taraballi
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Aug 10, 2021·ACS Applied Bio Materials·Maya HolayLiangfang Zhang
Aug 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi ZhaoBowen Wang

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Methods Mentioned

BETA
X-ray
coronary artery bypass
biosensors
biosensor
imaging techniques
imaging technique
imaging
fluorescence imaging
nanoprecipitation
transfection

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