Biomimetic Pulsating Vesicles with Both pH-Tunable Membrane Permeability and Light-Triggered Disassembly-Re-assembly Behaviors Prepared by Supra-Amphiphilic Helices

ACS Applied Materials & Interfaces
Tengfei YanJunqiu Liu

Abstract

The reversible unfolding-refolding transition is considerably important for natural elastomeric proteins (e.g., titin) to fulfill their biological functions. It is of great importance to develop synthetic versions by borrowing their unique stretchable design principles. Herein, we present a novel pulsating vesicle by means of the aqueous self-assembly of supra-amphiphilic helices. Interestingly, this vesicle simultaneously features dynamic swelling and shrinkage movements in response to external proton triggers. Titin-like unfolding-refolding transformation of artificial helices was proved to play a crucial role in this pulsatile motion. Moreover, the vesicular membrane of this vesicle has exhibited tunable permeability during reversible expansion and contraction circulation. Meanwhile, light can also be used as a driving force to further regulate the disassembly-reassembly transformation of the pulsating vesicle. In addition, the drug delivery system was also employed as an investigating model to estimate the permeability variation and disassembly-reassembly behaviors of the pulsating vesicles, which displayed unique dual quick- and sustained-release behaviors toward anti-cancer agents. It is anticipated that this work opens a...Continue Reading

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Citations

Aug 31, 2020·Advanced Healthcare Materials·Loredana LeggioNunzio Iraci
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samuele Rinaldi
Jun 4, 2020·Physical Chemistry Chemical Physics : PCCP·Peng LiuDonghai Mei
Oct 1, 2021·Chemistry : a European Journal·Yixin ChenHao Li

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