Biomimetic scaffold containing PVDF nanofibers with sustained TGF-β release in combination with AT-MSCs for bladder tissue engineering

Gene
A ArdeshirylajimiSadegh Lotfalah Moradi

Abstract

Since the functional recovery of the reconstructed bladder is related to the bladder wall contraction and existing therapies do not respond to this, tissue engineering could be worth considered promising candidates for developing of conventional treatments in these kinds of ailments. Due to the low mechanical properties of natural scaffolds, biocompatible synthetic scaffolds can play a key role in the stem cells proliferation and differentiation and apply for many tissue-engineering applications. On the other hand, considering the low shelf life of TGFβ, encapsulating this growth factor can help maintain its functionality throughout the study period. In this study, poly (vinylidene fluoride) (PVDF) nanofibrous scaffolds were fabricated through electrospinning method with or without chitosan nanoparticles loaded TGFβ. All scaffolds characterized morphologically by using SEM, TGFβ release profiling as well as biocompatibility by using SEM and MTT assays. Adipose tissue derived mesenchymal stem cells (AT-MSCs) was isolated and characterized immediately and the differentiation of SMC was investigated when cultured on the surface of the scaffolds and tissue culture polystyrene (TCPS) as a control of gene and protein expression level...Continue Reading

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Citations

Jul 25, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Ali MirzaeiFatemeh Soleimanifar
Jun 10, 2020·International Journal of Molecular Sciences·Juliana BaranovaEdda Tobiasch
Apr 21, 2020·In Vitro Cellular & Developmental Biology. Animal·Zakiye MokhamesMir Davood Omrani
Apr 17, 2019·Nanomaterials·S M Shatil ShahriarYong-Kyu Lee
Oct 30, 2020·Frontiers in Bioengineering and Biotechnology·Masoud ZamaniMohammad Naji
Dec 21, 2020·Advances in Colloid and Interface Science·Joëlle Bizeau, Damien Mertz

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