Biomimetic scaffolds based on hydroxyapatite nanorod/poly(D,L) lactic acid with their corresponding apatite-forming capability and biocompatibility for bone-tissue engineering

Colloids and Surfaces. B, Biointerfaces
Nguyen Kim NgaPham Hung Viet

Abstract

This study presents a facile synthesis of biomimetic hydroxyapatite nanorod/poly(D,L) lactic acid (HAp/PDLLA) scaffolds with the use of solvent casting combined with a salt-leaching technique for bone-tissue engineering. Field emission scanning electron microscopy, Fourier transform infrared spectroscopy, and energy-dispersive X-ray spectroscopy were used to observe the morphologies, pore structures of synthesized scaffolds, interactions between hydroxyapatite nanorods and poly(D,L) lactic acid, as well as the compositions of the scaffolds, respectively. Porosity of the scaffolds was determined using the liquid substitution method. Moreover, the apatite-forming capability of the scaffolds was evaluated through simulated body fluid (SBF) incubation tests, whereas the viability, attachment, and distribution of human osteoblast cells (MG 63 cell line) on the scaffolds were determined through alamarBlue assay and confocal laser microscopy after nuclear staining with 4',6-diamidino-2-phenylindole and actin filaments of a cytoskeleton with Oregon Green 488 phalloidin. Results showed that hydroxyapatite nanorod/poly(D,L) lactic acid scaffolds that mimic the structure of natural bone were successfully produced. These scaffolds possesse...Continue Reading

References

Jul 25, 2000·Biomaterials·T J WebsterR Bizios
Nov 9, 2000·Biomaterials·D W Hutmacher
Dec 13, 2005·Biomaterials·Qizhi Z ChenAldo R Boccaccini
Feb 2, 2006·Biomaterials·Tadashi Kokubo, Hiroaki Takadama
Aug 16, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·ZuFu LuHala Zreiqat
Jul 17, 2012·Colloids and Surfaces. B, Biointerfaces·Hongjie HuChuanxian Ding
Oct 31, 2012·Colloids and Surfaces. B, Biointerfaces·Abdalla Abdal-hayJae Kyoo Lim
Apr 16, 2013·Acta Biomaterialia·Mehdi Sadat-ShojaiAhmad Jamshidi
Jul 24, 2013·Colloids and Surfaces. B, Biointerfaces·Nazia MehrbanLiam M Grover
Nov 28, 2013·Colloids and Surfaces. B, Biointerfaces·Nguyen Kim NgaClaudio Migliaresi

❮ Previous
Next ❯

Citations

Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Eric Reyes CervantesRogelio Rodríguez Talavera
Jul 12, 2016·Journal of Biomaterials Science. Polymer Edition·Guiyong XiaoYupeng Lu
Apr 8, 2017·Journal of Materials Science. Materials in Medicine·Vera GuduricSylvain Catros
Jun 1, 2017·Biotechnology Advances·Sheva NaahidiP Chen
Dec 31, 2019·International Journal of Dentistry·Sandra Janeth Gutiérrez-PrietoAdriana P Acosta
Jun 5, 2017·Scientific Reports·Kazuo Onuma, Mayumi Iijima
Apr 27, 2021·Journal of Orthopaedic Translation·Zeyu FuKaili Lin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.