Biomimetic Silica Nanocapsules for Tunable Sustained Release and Cargo Protection

Langmuir : the ACS Journal of Surfaces and Colloids
Guang-Ze YangChun-Xia Zhao

Abstract

Silica nanocapsules have attracted tremendous interest for encapsulation, protection, and controlled release of various cargoes due to their unique hierarchical core-shell structure. However, it remains challenging to synthesize silica nanocapsules having high cargo-loading capacity and cargo-protection capability without compromising process simplicity and biocompatibility properties. Here, we synthesized oil-core silica-shell nanocapsules under environmentally friendly conditions by a novel emulsion and biomimetic dual-templating approach using a dual-functional protein, in lieu of petrochemical surfactants, thus avoiding the necessities for the removal of toxic components. A light- and pH-sensitive compound can be facilely encapsulated in the silica nanocapsules with the encapsulation efficiency of nearly 100%. Release of the encapsulated active from the nanocapsules was not shown an indication of undesired burst release. Instead, the release can be tuned by controlling the silica-shell thicknesses (i.e., 40 and 77 nm from which the cargo released at 42.0 and 31.3% of the initial amount after 32 days, respectively). The release kinetics were fitted well to the Higuchi model, enabling the possibility of the prediction of rele...Continue Reading

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Citations

Aug 1, 2019·Angewandte Chemie·Guangze YangChun-Xia Zhao
Apr 30, 2020·Chembiochem : a European Journal of Chemical Biology·Guangze YangChun-Xia Zhao
Aug 31, 2020·ChemPlusChem·Yun LiuChun-Xia Zhao
Jun 1, 2021·Journal of Colloid and Interface Science·Russell J WilsonChun-Xia Zhao
Aug 11, 2020·Journal of Colloid and Interface Science· TengjisiChun-Xia Zhao

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