Biomimetic Silk Scaffolds with an Amorphous Structure for Soft Tissue Engineering.

ACS Applied Materials & Interfaces
Yonghuan SangDavid Kaplan

Abstract

Fine tuning physical cues of silk fibroin (SF) biomaterials to match specific requirements for different soft tissues would be advantageous. Here, amorphous SF nanofibers were used to fabricate scaffolds with better hierarchical extracellular matrix (ECM) mimetic microstructures than previous silk scaffolds. Kinetic control was introduced into the scaffold forming process, resulting in the direct production of water-stable scaffolds with tunable secondary structures and thus mechanical properties. These biomaterials remained with amorphous structures, offering softer properties than prior scaffolds. The fine mechanical tunability of these systems provides a feasible way to optimize physical cues for improved cell proliferation and enhanced neovascularization in vivo. Multiple physical cues, such as partly ECM mimetic structures and optimized stiffness, provided suitable microenvironments for tissue ingrowth, suggesting the possibility of actively designing bioactive SF biomaterials. These systems suggest a promising strategy to develop novel SF biomaterials for soft tissue repair and regenerative medicine.

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Citations

Jun 18, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhihai FanQiang Lu
Nov 19, 2019·Macromolecular Bioscience·Jiawei LiuQiang Lu
Apr 21, 2020·Journal of Biomaterials Science. Polymer Edition·Haiying GaoChuanbao Cao
Oct 23, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue WangDavid L Kaplan
Dec 24, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liying XiaoDavid L Kaplan
Nov 5, 2019·Advanced Drug Delivery Reviews·Mazaher GholipourmalekabadiSubhas C Kundu
Feb 18, 2021·The Journal of Physical Chemistry. B·Romeo C A DubiniPetra Rovó
Apr 1, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Constantine TarabanisElliot L Chaikof
Apr 10, 2021·ACS Biomaterials Science & Engineering·Xiaoyi ZhangDavid L Kaplan
Apr 22, 2021·Biomaterials Science·Lijun WuDavid L Kaplan
May 14, 2021·International Journal of Biological Macromolecules·Zhinan MaoSujun Wu
Nov 5, 2019·ACS Applied Materials & Interfaces·Fengrui XuDavid L Kaplan
Jun 10, 2019·ACS Biomaterials Science & Engineering·Yingjie HangDavid L Kaplan
Jan 19, 2021·ACS Biomaterials Science & Engineering·Zhaozhao DingDavid L Kaplan
Jan 19, 2021·ACS Biomaterials Science & Engineering·Jian LiuXiaoqin Wang

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