Biomimetic tumor microenvironments based on collagen matrices

Biomaterials Science
Jiranuwat Sapudom, Tilo Pompe

Abstract

The extracellular matrix (ECM) establishes the basis for the cell's microenvironment providing structural and mechanical support to cells and tissues, and regulating multiple cell functions including gene expression, cell cycle, apoptosis, morphogenesis, and migration. Tumor development can be considered as a process where the cells are subjected to mutations. However, changes in the microenvironment of tumor cells can strongly impact the growth, invasion and survival of tumor cells. This specialized microenvironment is known to have an abundance of inflammatory cells and activated fibroblasts both expressing ECM components and growth factors that support the survival and proliferation of tumor cells in a paracrine fashion. Growing evidence points towards a key role of the ECM in the modulation of tumor progression and metastasis, even influencing therapeutic pharmacosensitivity. Accordingly, to better understand the mechanisms of tumor cell behavior, e.g. proliferation, invasion and survival, in dependence on microenvironmental cues as well as the cell-microenvironment interaction, it is necessary to engineer well-defined 3D matrices to closely mimic in vivo like microenvironments in a controlled in vitro setting. In that way ...Continue Reading

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Citations

Dec 6, 2018·Advanced Healthcare Materials·Ini-Isabée WitzelJeremy C M Teo
Aug 20, 2020·Biomaterials Science·Jiranuwat SapudomJeremy C M Teo
Aug 19, 2020·Macromolecular Bioscience·Candy LöwenbergAndreas Lendlein
Oct 24, 2020·Cells·Hisham F BahmadMohamed Al-Sayegh
Nov 25, 2020·Biomaterials Science·Ines CadenaKaitlin C Fogg
Feb 27, 2021·PLoS Computational Biology·Inês G Gonçalves, Jose Manuel Garcia-Aznar
Mar 7, 2021·Gels·Xabier MoralesCarlos Ortiz-de-Solorzano
Apr 26, 2021·Advanced Drug Delivery Reviews·Marcel A HeinrichJai Prakash
May 1, 2021·Bioengineering·Mahta MirzaeiAmin Shavandi
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kichul KimSangho Roh
Jun 12, 2021·Acta Biomaterialia·Shalini R Unnikandam VeettilIan C Schneider

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Methods Mentioned

BETA
imaging techniques
transfection
fluorescence microscopy
confocal microscopy

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