Biomimetics of fetal alveolar flow phenomena using microfluidics

Biomicrofluidics
Janna Tenenbaum-KatanJosué Sznitman

Abstract

At the onset of life in utero, the respiratory system begins as a liquid-filled tubular organ and undergoes significant morphological changes during fetal development towards establishing a respiratory organ optimized for gas exchange. As airspace morphology evolves, respiratory alveolar flows have been hypothesized to exhibit evolving flow patterns. In the present study, we have investigated flow topologies during increasing phases of embryonic life within an anatomically inspired microfluidic device, reproducing real-scale features of fetal airways representative of three distinct phases of in utero gestation. Micro-particle image velocimetry measurements, supported by computational fluid dynamics simulations, reveal distinct respiratory alveolar flow patterns throughout different stages of fetal life. While attached, streamlined flows characterize the shallow structures of premature alveoli indicative of the onset of saccular stage, separated recirculating vortex flows become the signature of developed and extruded alveoli characteristic of the advanced stages of fetal development. To further mimic physiological aspects of the cellular environment of developing airways, our biomimetic devices integrate an alveolar epithelium...Continue Reading

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Citations

Sep 29, 2018·The European Respiratory Journal·Konstantinos GkatzisSaverio Bellusci
Jun 12, 2018·Biomicrofluidics·Janna Tenenbaum-KatanJosué Sznitman
Jul 11, 2020·Advanced Biosystems·Arbel Artzy-SchnirmanJosué Sznitman
Jan 13, 2018·Biomaterials Science·James C H PoonThomas K Waddell
Aug 1, 2021·Advanced Drug Delivery Reviews·Arbel Artzy-SchnirmanJosué Sznitman

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