Biominerals Formed by DNA and Calcium Oxalate or Hydroxyapatite: A Comparative Study

Langmuir : the ACS Journal of Surfaces and Colloids
Guillem Revilla-LópezCarlos Alemán

Abstract

Biominerals formed by DNA and calcium oxalate (CaOx) or hydroxyapatite (HAp), the most important and stable phase of calcium phosphate) have been examined and compared using a synergistic combination of computer simulation and experimental studies. The interest of this comparison stems from the medical observation that HAp- and CaOx-based microcalcifications are frequently observed in breast cancer tissues, and some of their features are used as part of the diagnosis. Molecular dynamics simulations show that (1) the DNA double helix remains stable when it is adsorbed onto the most stable facet of HAp, whereas it undergoes significant structural distortions when it is adsorbed onto CaOx; (2) DNA acts as a template for the nucleation and growth of HAp but not for the mineralization of CaOx; and (3) the DNA double helix remains stable when it is encapsulated inside HAp nanopores, but it becomes destabilized when the encapsulation occurs into CaOx nanopores. Furthermore, CaOx and HAp minerals containing DNA molecules inside and/or adsorbed on the surface have been prepared in the lab by mixing solutions containing the corresponding ions with fish sperm DNA. Characterization of the formed minerals, which has been focused on the iden...Continue Reading

References

Aug 3, 2002·Oncogene·Martin Widschwendter, Peter A Jones
Apr 30, 2004·Journal of Computational Chemistry·Junmei WangDavid A Case
Dec 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Xiaoxia ShengMichael D Ward
Aug 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Abigail S HakaMichael S Feld
Oct 14, 2005·Journal of Computational Chemistry·James C PhillipsKlaus Schulten
Aug 4, 2007·Breast Cancer Research and Treatment·Gary M TseWynnie W M Lam
Sep 28, 2007·Urological Research·S Sandersius, P Rez
Apr 29, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Neyvis Almora-BarriosNora H de Leeuw
Feb 24, 2010·Journal of Colloid and Interface Science·Guo-Jun WuHong-Chen Gu
Apr 20, 2010·Angewandte Chemie·David A GiljohannChad A Mirkin
Jun 15, 2010·Applied and Environmental Microbiology·Cynthia Andrews-PfannkochShannon J Williamson
Sep 16, 2010·British Journal of Cancer·R BakerN Stone
Sep 28, 2010·Chemical Society Reviews·Shiping SongHong-Yuan Chen
Nov 10, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vuk Uskoković, Dragan P Uskoković
Jul 31, 2012·PloS One·Marc GuéroultBrigitte Hartmann
Jul 19, 2013·ACS Applied Materials & Interfaces·Rachel PautlerJuewen Liu
Aug 29, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Takayuki TakeshitaMasami Okamoto
Oct 10, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Oscar BertranCarlos Alemán
Apr 8, 2014·Biointerphases·Guillermo Revilla-LópezCarlos Alemán
Dec 17, 2014·Chemistry : a European Journal·Oscar BertranCarlos Alemán
Feb 24, 2015·Science·Matthew R JonesChad A Mirkin
May 7, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Manuel RivasCarlos Alemán
Apr 10, 2012·Journal of Chemical Theory and Computation·Olof AllnérAlessandra Villa
Apr 3, 2016·Chemistry : a European Journal·Oscar BertranCarlos Alemán
Jun 10, 2017·Chemical Reviews·Wenhu ZhouJuewen Liu
Nov 11, 2017·Nature Communications·Thomas FleischerVessela N Kristensen
Oct 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Luis J Del ValleCarlos Alemán

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Citations

Apr 13, 2020·Analytica Chimica Acta·Emma DuffyAren E Gerdon

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