Biomolecular events involved in the establishment of brain anticandidal resistance

Journal of Neuroimmunology
R MazzollaE Blasi

Abstract

Using a murine model, we have demonstrated the establishment of cerebral resistance to local lethal challenge with Candida albicans strain CA-6, by previous intracerebral (i.c.) infection with the low-virulent strain PCA-2. Here we show that i.c. infection with PCA-2 is effective in drastically reducing brain colonization following secondary infection with CA-6. As assessed by colony forming unit assay and histopathological analysis, microbial counts are impaired, granuloma formation and hyphal growth are also reduced in brains of PCA-2- and CA-6-infected mice with respect to CA-6-challenged mice. Furthermore, using PCR studies, we found that, while PCA-2 (i.e. healing infection) induces transient cytokine gene expression in the mouse brain, CA-6 lethal challenge results in long-lasting (until mouse death) high levels of all cytokine gene transcripts assessed. Finally brains from mice that will resist CA-6 challenge, because of previous infection with PCA-2, also exhibit a transient induction of all cytokine genes. Only IL-1 beta remains highly expressed at all time- points tested. Overall, these results provide evidence that healing and non-healing C. albicans i.c. infections differ in the immune reaction(s) locally evoked, at...Continue Reading

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Citations

Apr 1, 2000·Journal of Neuroimmunology·M KretschmarT Nichterlein
May 18, 2000·Journal of Neuroimmunology·N PolentaruttiA Mantovani
May 29, 2010·Medical Mycology·Carlotta Francesca OrsiElisabetta Blasi
Oct 31, 1998·Antimicrobial Agents and Chemotherapy·J R GraybillT F Patterson

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