Biomolecular information gained through in vitro evolution

Biophysics Reviews
Takuyo Aita, Yuzuru Husimi

Abstract

An in vitro evolution is a simplified Darwinian evolution in well-controlled surroundings. This evolution process can be modeled as a hill-climbing or adaptive walk on a fitness landscape in sequence space. The evolving molecular system gains at least two kinds of information originating from the converged sequences and the fitness increment of the evolving biopolymer as the adaptive walker. These two represent two aspects of the biomolecular information, its extent and its content, respectively. Here, we review studies related to formulation of the "content" and "extent" of biomolecular information. The two aspects are interconnected through physicochemical properties of the biopolymer, contrary to the case of conventional information, which seems to be independent of matter. The interconnection was analyzed based on the analogy between the evolution process and thermodynamics. The linear combination of the two by a temperature-like fluctuation factor resulted in a free-energy-like monotonically increasing function during the evolution process.

References

Jan 1, 1988·Bulletin of Mathematical Biology·P Schuster, J Swetina
Dec 7, 1988·Journal of Theoretical Biology·Y Iwasa
Jul 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·D R MillsS Spiegelman
Dec 31, 1997·Biophysical Journal·V S PandeT Tanaka
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·C AdamiT C Collier
Jul 25, 2000·Nucleic Acids Research·T D Schneider
Aug 29, 2000·Biophysical Chemistry·M Eigen
Mar 8, 2003·Journal of Theoretical Biology·Jan T KimDaniel Polani
Jun 13, 2003·Nature·Jack W Szostak
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Katsuhiko SatoKunihiko Kaneko
Aug 6, 2004·Bulletin of Mathematical Biology·Takuyo AitaYuzuru Husimi
Oct 29, 2005·The Journal of Chemical Physics·Benjamin P Blackburne, Jonathan D Hirst
Dec 8, 2007·Theoretical Biology & Medical Modelling·Kirk K DurstonJack T Trevors
Mar 28, 2008·Journal of Theoretical Biology·Eric Smith
Mar 28, 2008·Journal of Theoretical Biology·Eric Smith

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Citations

Dec 2, 2015·Psychological Medicine·S JoyceS B Harvey

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