Biomolecular Interaction, Anti-Cancer and Anti-Angiogenic Properties of Cobalt(III) Schiff Base Complexes

Scientific Reports
Subramanian AmbikaMuthuraman Sundararaman

Abstract

Two cobalt(III) Schiff base complexes, trans-[Co(salen)(DA)2](ClO4) (1) and trans-[Co(salophen)(DA)2](ClO4) (2) (where salen: N,N'-bis(salicylidene)ethylenediamine, salopen: N,N'-bis(salicylidene)-1,2-phenylenediamine, DA: dodecylamine) were synthesised and characterised using various spectroscopic and analytical techniques. The binding affinity of both the complexes with CT-DNA was explored adopting UV-visible, fluorescence, circular dichroism spectroscopy and cyclic voltammetry techniques. The results revealed that both the complexes interacted with DNA via intercalation as well as notable groove binding. Protein (BSA) binding ability of these complexes was investigated by absorption and emission spectroscopy which indicate that these complexes engage in strong hydrophobic interaction with BSA. The mode of interaction between these complexes and CT-DNA/BSA was studied by molecular docking analysis. The in vitro cytotoxic property of the complexes was evaluated in A549 (human small cell lung carcinoma) and VERO (African green monkey kidney cells). The results revealed that the complexes affect viability of the cells. AO and EB staining and cell cycle analysis revealed that the mode of cell death is apoptosis. Both the complexe...Continue Reading

References

Aug 12, 1971·The New England Journal of Medicine·J Folkman
Nov 25, 1993·Nucleic Acids Research·S A WoodsonS E Rokita
Jul 29, 1996·International Journal of Cancer. Journal International Du Cancer·M V Blagosklonny, W S el-Deiry
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·N PoklarK J Breslauer
Apr 5, 2001·Journal of Virology·J A SchwartzS J Silverstein
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe GiacconeDavid H Johnson
Apr 16, 2004·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Dilson SilvaSônia R W Louro
Nov 13, 2004·Journal of Medicinal Chemistry·Ronald GustKlaus Sommer
Aug 30, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tetsuhiro TanakaMasaomi Nangaku
Dec 6, 2008·Inorganic Chemistry·Debojyoti LahiriAkhil R Chakravarty
Jul 30, 2010·Colloids and Surfaces. B, Biointerfaces·Gopa MandalTapan Ganguly
Jul 31, 2010·Journal of Medicinal Chemistry·Soo-Young LeeRonald Gust
Sep 8, 2010·Chemical Society Reviews·Antonella Dalla CortFrancesco Yafteh Mihan
May 4, 2011·Journal of Medicinal Chemistry·Patrycja Nowak-SliwinskaArjan W Griffioen
May 20, 2011·Journal of Agricultural and Food Chemistry·Xingren PanJing Wang
Aug 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Caiping TanAnlong Xu
Nov 24, 2011·Bioinorganic Chemistry and Applications·Nahid ShahabadiAzadeh Fatahi
Jun 29, 2012·Chemical Communications : Chem Comm·Shuho TanimotoKazunobu Toshima
Sep 21, 2012·Acta Crystallographica. Section D, Biological Crystallography·Anna Bujacz
Nov 16, 2012·Nanoscale·Ayan Kumar BaruiChitta Ranjan Patra
Jun 12, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·G VigneshR Arthur James
May 24, 2014·Journal of Biomolecular Structure & Dynamics·Jagadeesan LakshmiprabaMohammad Abdulkader Akbarsha
Jun 7, 2014·Journal of the American Chemical Society·Yao-Rong ZhengStephen J Lippard
Jan 13, 2015·Journal of Medicinal Chemistry·Ana ZamoraJosé Ruiz
Jun 13, 2015·Journal of Medicinal Chemistry·Penumaka NagababuBojja Sreedhar
Jul 8, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Catherine R Munteanu, Kogularamanan Suntharalingam
Aug 8, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·G VigneshK Premkumar
Nov 3, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Anup PaulArmando J L Pombeiro
Feb 18, 2016·Cancer Chemotherapy and Pharmacology·Shahana Dilruba, Ganna V Kalayda
Dec 28, 2016·Journal of Chemical Information and Modeling·Rajendran SenthilkumarMark S Johnson

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Citations

May 31, 2019·Journal of Biomolecular Structure & Dynamics·Selvan NehruSelvakumar Veeralakshmi
Oct 17, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniel BaeckerRonald Gust
Mar 1, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Hana CrlikovaJana Kasparkova
Nov 12, 2020·International Journal of Molecular Sciences·Laísa de P FernandesCarolina G Oliveira
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ubale Panchsheela AshokDaniel Glossman-Mitnik
Jun 23, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Balakrishnan GowdhamiMohammad A Akbarsha
Dec 23, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Balakrishnan GowdhamiMohammad Abdulkader Akbarsha

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Methods Mentioned

BETA
Circular
Fluorescence
silica gel column chromatography
flow cytometry
FACS

Software Mentioned

Gaussian09
angioquant
Dean
Autodock
AUTODOCK4
Jett
- Fox
G09W

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