Biomolecular predictors of urothelial cancer behavior and treatment outcomes.

Current Urology Reports
Michael RinkShahrokh F Shariat

Abstract

Urothelial carcinoma of the urinary bladder (UCB) is a highly heterogeneous malignancy that causes significant morbidity and mortality. Despite advances in surgical and medical treatment, there has been no change in mortality in UCB over the past decades. Standard pathological features (stage, grade, nodal status) provide only limited information regarding biological potential and clinical behavior. Molecular biomarkers may shed light on important mechanisms of pathogenesis, provide useful additional prognostic information, and serve as targets for therapy. This review summarizes recent advances and the most promising UCB tissue and blood biomarkers of the past few years. We discuss the predictive and prognostic value of biomarkers at different stages of UCB. There is no doubt that a panel of biomarkers will eventually improve our clinical decision-making with regard to treatment and follow-up.

References

Mar 1, 1993·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·G DalbagniC Cordon-Cardo
Nov 10, 1994·The New England Journal of Medicine·D EsrigR J Cote
Aug 21, 1993·Lancet·G DalbagniC Cordon-Cardo
Jul 22, 1998·Journal of the National Cancer Institute·J P SteinR J Cote
Jul 27, 1999·The Journal of Biological Chemistry·H Nagase, J F Woessner
Dec 1, 2000·Nature·B VogelsteinA J Levine
Feb 15, 2001·JAMA : the Journal of the American Medical Association·S D SmithD C Altieri
Aug 21, 2001·Journal of Insurance Medicine·M Moore
Nov 15, 2002·International Journal of Cancer. Journal International Du Cancer·Stefan KrügerAndreas Böhle
Nov 20, 2003·Urology·Kaija VasalaTaina Turpeenniemi-Hujanen
Jan 10, 2004·The Journal of Urology·Shahrokh F ShariatSeth P Lerner
Feb 26, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shahrokh F ShariatSeth P Lerner
Feb 26, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sunanda J ChatterjeeRichard J Cote
Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
May 4, 2005·Cancer Research·Whitney SalzDario C Altieri
Sep 1, 2005·The Lancet Oncology·Núria MalatsFrancisco X Real
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yasuyoshi MiyataHiroshi Kanetake
Jul 25, 2006·Clinical Genitourinary Cancer·Anirban P MitraRichard J Cote
Jul 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Bladder Cancer Nomogram ConsortiumKinjal C Vora
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shahrokh F ShariatSeth P Lerner
Dec 13, 2006·The Journal of Urology·P M J MoonenJ A Witjes
Dec 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vitaly MargulisYair Lotan
Mar 27, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shahrokh F ShariatYair Lotan
Oct 27, 2007·World Journal of Urology·Vitaly MargulisShahrokh F Shariat
Dec 20, 2007·Current Opinion in Urology·Shahrokh F ShariatSeth P Lerner
Aug 30, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Young Kyoon Kim, Wun-Jae Kim
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johann S de BonoDerek Raghavan
Oct 7, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D J GallagherD F Bajorin

❮ Previous
Next ❯

Citations

May 24, 2014·Cancer Genetics·Martina KluthSarah Minner
Apr 24, 2014·Current Urology Reports·Marianne SchmidMichael Rink
Jun 9, 2015·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Oct 22, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E XylinasS F Shariat
Sep 11, 2012·BJU International·David A GreenRichard K Lee
Sep 4, 2012·BJU International·Michael RinkUNKNOWN Bladder Cancer Research Consortium
Feb 3, 2015·Proteomics. Clinical Applications·Martin PejchinovskiThomas Koeck
Aug 5, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Georgios GakisMichael Rink
Mar 17, 2015·Mutation Research·André Luiz Ventura SávioDaisy Maria Fávero Salvadori
Jun 3, 2014·Current Opinion in Urology·Kathrin SimonisMichael Rink
Oct 23, 2015·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yuan-Feng TianQian-Yuan Zhuang
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Orcun CelikYusuf Ozlem Ilbey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved