Biomonitoring of nutritional acrylamide intake by consumers without dietary preferences as compared to vegans

Archives of Toxicology
Katharina GoerkeElke Richling

Abstract

Acrylamide (AA) is a heat-induced food contaminant considered as genotoxic carcinogen. The present study investigated the influence of nutritional and lifestyle preferences on human AA exposure. A 10-day human study was performed with ten volunteers without nutritional preferences (omnivores) and ten vegans. Volunteers self-reported their daily routine and dietary habits. Overall mean AA intake, calculated from contents of diet duplicates, was 0.32 ± 0.19 µg/kg body weight (bw)/day with marked inter-day and inter-volunteer variabilities. Vegans ingested more AA (0.38 ± 0.23 µg/kg bw/day) than omnivore volunteers without dietary restrictions (0.26 ± 0.10 µg/kg bw/day). Excretion kinetics of urinary AA-related mercapturic acids N-acetyl-S-(2-carbamoylethyl)-L-cysteine and N-acetyl-S-(2-hydroxy-2-carbamoylethyl)-L-cysteine were essentially concordant with the respective dietary AA intake. Disproportionately enhanced AA-related biomarker excretion could be traced back to reportedly inadvertent, passive exposure to tobacco and/or fire smoke, as evidenced by the respective urinary exposure biomarkers, cotinine and N-acetyl-S-(2-cyanoethyl)-L-cysteine. Although the study is based on the comparison of small volunteer groups, the result...Continue Reading

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Citations

Nov 22, 2019·Molecular Nutrition & Food Research·Meike RuenzElke Richling
Jun 17, 2020·Archives of Toxicology·Andrea HartwigGerhard Eisenbrand
Mar 14, 2020·International Journal of Environmental Research and Public Health·Gianfranco FrigerioSilvia Fustinoni
Aug 7, 2021·Environmental Research·Sandra F FernándezUNKNOWN BETTERMILK project

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reversed phase chromatography

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