Biomonitoring of Urinary Benzene Metabolite SPMA in the General Population in Central Italy

Toxics
Giovanna TranfoCarla Ancona

Abstract

Benzene is an important component of cigarette smoke and car exhaust. Products containing benzene in concentrations greater than 0.1% are prohibited in Europe, but 1% of benzene is still allowed in gasoline. The purpose of the study was to assess the levels of urine benzene biomarkers in a sample of the general population not occupationally exposed to benzene, resident in the period 2013⁻2014 in Central Italy, compared to other groups. The urinary levels of the benzene metabolites S-phenyl-mercapturic acid (SPMA) and cotinine (nicotine metabolite) were determined by means of HPLC with mass spectrometric detection in 1076 subjects. The median SPMA value in smokers was 1.132 µg/g of creatinine while in non-smokers it was 0.097 µg/g of creatinine, and the 95th percentile results were seven times higher. The main source of benzene exposure in the studied population was active smoking, however, non-smokers were also exposed to airborne benzene concentrations. The concentration ranges found in this study can be used as a background reference for occupational exposure assessment to benzene by means of SPMA biomonitoring.

References

Jul 1, 1994·American Journal of Industrial Medicine·B I Castleman, G E Ziem
Sep 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Silvia FustinoniDomenico F Merlo
Jan 31, 2007·The Science of the Total Environment·Eric S JohnsonYu-Sheng Lin
Jan 25, 2008·Archives of Environmental Contamination and Toxicology·C ApreaG B Bartolucci
Dec 22, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Silvia FustinoniPaola Manini
Jul 2, 2010·Environment International·Carmela ProtanoMatteo Vitali
Mar 23, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Silvia FustinoniPier Alberto Bertazzi
Jan 26, 2013·Critical Reviews in Toxicology·Scott M ArnoldA Robert Schnatter
Apr 27, 2013·International Journal of Hygiene and Environmental Health·J Tuakuila
Jun 27, 2014·Toxicology Letters·Damiano CarbonariAntonella Mansi

❮ Previous
Next ❯

Citations

Jan 10, 2019·International Journal of Environmental Research and Public Health·Mariella CarrieriGiovanna Tranfo
Sep 27, 2020·International Journal of Environmental Research and Public Health·Chin-Yu HsuChih-Da Wu
Sep 24, 2021·Biology of Reproduction·Kathrin M EngelSonja Grunewald

❮ Previous
Next ❯

Software Mentioned

SAS
STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wei sheng yan jiu = Journal of hygiene research
Yu-Jie YeFang-Li Ye
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Yong MeiFang-Li Ye
International Journal of Environmental Research and Public Health
Mariella CarrieriGiovanna Tranfo
© 2022 Meta ULC. All rights reserved