Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients

Toxicology Reports
Belén FernándezSabine Hilfiker

Abstract

Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinson's disease (PD) patients as compared to controls, which correlates with motor disability. Here, we have analyzed total iron levels in cells as well as mouse and human brain samples by atomic absorption spectroscopy (AAS). Our data indicate that iron load is more pronounced in cells with dopaminergic features. Moreover, region-specific differences in iron load reflecting those in the human brain were detected in rodent brains as well. Whilst altered iron load was not observed in other regions also affected in PD patients, we report a significant increase in iron load in the SN of Lewy body disease patients as compared to Alzheimer's disease (AD) patients or controls, which correlates with neurodegeneration in this brain area.

References

Jan 1, 1968·Journal of Neuropathology and Experimental Neurology·K M Earle
Dec 1, 1994·Annals of Neurology·V M MannA H Schapira
Jan 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·J Gałazka-FriedmanI Nowik
Dec 28, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael J HouseLee-Way Jin
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cristina MalageladaLloyd A Greene
Oct 6, 2009·Neuroscience Letters·Suzanne TimmonsCora O' Neill
May 7, 2011·Cellular and Molecular Neurobiology·Lloyd A GreeneCristina Malagelada
Sep 13, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Guangwei DuXuemei Huang
Nov 8, 2015·Journal of Neurochemistry·Abdel A Belaidi, Ashley I Bush

❮ Previous
Next ❯

Citations

Mar 18, 2020·Journal of Molecular Neuroscience : MN·Yumei LiuAnmu Xie
Feb 7, 2020·Journal of Neural Transmission·Hideki MochizukiKousuke Baba
Mar 19, 2019·Frontiers in Neuroscience·Alain NdayisabaGregor K Wenning
Oct 24, 2018·Pharmaceuticals·Marco T Nuñez, Pedro Chana-Cuevas
Aug 24, 2019·Toxicology Reports·Omodesola Oluwafisayo OgunrukuAline Augusti Boligon
Feb 13, 2021·Biosensors & Bioelectronics·Shaopei Li, Kagan Kerman
Apr 4, 2021·International Journal of Molecular Sciences·Roberta J WardRobert R Crichton
Oct 23, 2020·Pharmacology, Biochemistry, and Behavior·Tanvi Pingale, Girdhari Lal Gupta

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
scraping
electrophoresis

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.