Abstract
What is the topic of this review? This review discusses how implantation of continuous flow left ventricular assist devices impact arterial stiffness and outcome. What advances does it highlight? Not all patients implanted with continuous flow left ventricular assist devices show an increase in arterial stiffness. However, in those patients where arterial stiffness increases, levels of composite outcome (stroke, gastrointestinal bleeding, pump thrombosis and death) is significantly higher than those who's arterial stiffness does not increase. In parallel with the major advances in clinical care, technological advancements and implantation of mechanical circulatory support in patients with severe heart failure have resulted in these patients living longer. However, these patients are still at increased risk of stroke and gastrointestinal bleeding. The unique continuous flow produced by various left ventricular assist devices (LVADs) has been suggested as one potential reason for this increased risk of stroke and gastrointestinal bleeding. Furthermore, these continuous-flow (CF) devices challenge our understanding of circulatory blood pressure and flow regulation in relationship to organ health. In healthy pulsatile and dynamic s...Continue Reading
References
Jul 1, 1988·Biochemical Pharmacology·S MoncadaR M Palmer
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T NakanoH Yasui
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·F A DinennoH Tanaka
Feb 20, 2002·British Journal of Clinical Pharmacology·Ian B WilkinsonDavid J Webb
Mar 28, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Offer AmirFrank W Smart
Aug 31, 2006·Hypertension·Carmel M McEnieryIan B Wilkinson
Jan 20, 2010·Hypertension·Jeremy BellienRobinson Joannidès
Apr 14, 2012·Journal of Atherosclerosis and Thrombosis·Lee StonerKevin Kane McCully
Nov 19, 2013·Journal of the American College of Cardiology·Yoav Ben-ShlomoIan B Wilkinson
Jul 3, 2015·Circulation. Heart Failure·Amrut V AmbardekarJoAnn Lindenfeld
Aug 19, 2015·JACC. Heart Failure·Melissa A H WitmanRussell S Richardson
Oct 30, 2015·Circulation·William K CornwellBenjamin D Levine
Mar 13, 2017·JACC. Heart Failure·Amit C PatelAmrut V Ambardekar
Mar 13, 2018·The New England Journal of Medicine·Mandeep R MehraUNKNOWN MOMENTUM 3 Investigators
Dec 19, 2018·The Journal of Physiology·Eric J StöhrJoshua Z Willey
Dec 19, 2018·The Journal of Physiology·Eric J StöhrJoshua Z Willey
Dec 28, 2018·Circulation·Paolo C ColomboDouglas A Horstmanshof
Mar 19, 2019·The New England Journal of Medicine·Mandeep R MehraUNKNOWN MOMENTUM 3 Investigators
Apr 18, 2019·Experimental Physiology·Jem L ChengMaureen J MacDonald
Feb 28, 2020·Experimental Physiology·Eric J StöhrBarry J McDonnell