Bionomics and insecticides resistance profiling of malaria vectors at a selected site for experimental hut trials in central Cameroon

Malaria Journal
Benjamin D MenzeCharles S Wondji

Abstract

Malaria vectors are increasingly developing resistance to insecticides across Africa. The impact of such resistance on the continued effectiveness of insecticide-based interventions remains unclear due to poor characterization of vector populations. This study reports the characterization of malaria vectors at Mibellon, a selected site in Cameroon for experimental hut study, including species composition, Plasmodium infection rate, resistance profiles and mechanisms. Indoor resting blood-fed Anopheles mosquitoes were collected from houses at Mibellon in 2017 and forced to lay eggs to generate F1 adult mosquitoes. Insecticides susceptibility bioassays were performed on the F1 adult mosquitoes following the WHO protocol to assess resistance profile to insecticides. The molecular basis of resistance and Plasmodium infection rate were investigated using TaqMan genotyping. Anopheles funestus sensu stricto (s.s.) was predominant in Mibellon (80%) followed by Anopheles gambiae s.s. (20%). High levels of resistance to pyrethroids and organochlorides were observed for both species. Moderate resistance was observed against bendiocarb (carbamate) in both species, but relatively higher in An. gambiae s.s. In contrast, full susceptibility w...Continue Reading

References

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Oct 12, 2017·Parasites & Vectors·Christophe Antonio-NkondjioCharles S Wondji

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Citations

Oct 28, 2019·Parasites & Vectors·Christophe Antonio-NkondjioCharles S Wondji
Dec 5, 2019·Infectious Diseases of Poverty·Sulaiman S IbrahimCharles S Wondji
Sep 12, 2020·Parasites & Vectors·Eunice Oluwatobiloba AdedejiEzekiel Adebiyi
Oct 13, 2021·Parasites & Vectors·Roland BamouChristophe Antonio-Nkondjio

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Methods Mentioned

BETA
PCR
genotyping
fluorophores
FAM

Software Mentioned

PermaNet
Nkoteng
Cameron

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