Biopanel identifies expression status of targetable proteins in sinonasal melanoma

Personalized Medicine
Lisa GrünmüllerJochen K Lennerz

Abstract

Advanced stage at presentation, lack of BRAF mutations and overall rarity pose unique challenges to the therapy and trial design in sinonasal melanoma. Here, we assessed the expression status of 12 proteins in two independent cohorts of sinonasal melanoma (n = 20). Each case showed expression of at least one protein (KIT, TP53, MYC, HER2, EGFR, MET, VEGFR, BRAF V600E and/or MDM2), whereas lack of ALK, FLI1 and PDGFRα expression underscores differences to cutaneous melanoma. Comparison of marker frequencies to a metareview of the literature indicates that MYC, HER2, EGFR and MET had not been previously assessed. Expression of at least one potentially targetable protein per case illustrates proteome pathway profiling as one starting point for marker stratified trial design.

References

Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·A C LazarisP S Davaris
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Mar 14, 2002·Head & Neck·Snehal G PatelJatin P Shah
Apr 22, 2003·Pathology Oncology Research : POR·Erzsébet LengyelOlga Esik
Sep 23, 2003·Journal of Surgical Oncology·J Lucas InmanEdward A Levine
Mar 6, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sabrina RossiAngelo P Dei Tos
Apr 3, 2004·Journal of Medical Genetics·R H EdwardsB L Weber
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoram CohenWilliam H Westra
Apr 23, 2005·British Journal of Cancer·S UgurelD Schadendorf
Oct 22, 2005·Nature Reviews. Cancer·Joseph A Ludwig, John N Weinstein
Dec 1, 2005·American Journal of Clinical Oncology·William M MendenhallNancy Price Mendenhall
Mar 2, 2006·The Journal of Pathology·W ZhangH L McLeod
Mar 14, 2007·Journal of the American Academy of Dermatology·Ronald J PatrickJane L Messina
Nov 20, 2008·British Journal of Cancer·I SatzgerR Gutzmer
Jan 5, 2010·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Kailash NarasimhanRobert Mathog
Jun 19, 2010·The Journal of Molecular Diagnostics : JMD·Barbara A CentenoTimothy Y Yeatman
Jul 10, 2010·Oral Oncology·Heui June AhnSung Hyun Yang
Dec 7, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rupert LangerGisela Keller
Dec 22, 2010·Archives of Otolaryngology--head & Neck Surgery·Adil BenlyazidThomas Filleron
Feb 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yan KongJun Guo
Mar 1, 2011·Journal of Cutaneous Pathology·Barbara BooneLieve Brochez
May 5, 2011·Melanoma Research·Haim GavrielMichael Henderson
May 31, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·J ThariatL Castillo
Jun 7, 2011·JAMA : the Journal of the American Medical Association·Richard D CarvajalGary K Schwartz
Jun 22, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jun GuoShukui Qin
Nov 1, 2011·PloS One·Hazem El-OstaRazelle Kurzrock
Nov 11, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L V SequistD Dias-Santagata
Dec 6, 2011·Cancer Cell·Matija SnuderlA John Iafrate
Jan 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Daniel MullinsUNKNOWN American Society of Clinical Oncology
Mar 7, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·David G PfisterUNKNOWN National Comprehensive Cancer Network
Jul 24, 2012·Cell·Eran HodisLynda Chin
Sep 15, 2012·Experimental and Therapeutic Medicine·Sayaka KanetakaHideki Matsuda
Nov 29, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Valentina NardiDora Dias-Santagata
Mar 14, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Silvy da Rocha DiasFrancesco Pignatti
Apr 9, 2013·American Journal of Clinical Oncology·Kaitlin ChristophersonWilliam M Mendenhall
Jun 19, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Stephen HodiDavid E Fisher
Sep 21, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stephanie E WeissingerJochen K Lennerz
Jun 19, 2014·Oncotarget·Anna-Maria BubolzJochen K Lennerz

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Citations

Aug 30, 2019·Immunotherapy·Johannes DoescherPatrick J Schuler
Jul 30, 2020·Current Oncology Reports·Matt LechnerValerie J Lund

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Methods Mentioned

BETA
genotyping

Software Mentioned

Prism
pheatmap
Excel
R programming language environment

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