PMID: 11334335May 4, 2001Paper

Biopartitioning micellar chromatography: an in vitro technique for predicting human drug absorption

Journal of Chromatography. B, Biomedical Sciences and Applications
M Molero-MonfortM J Medina-Hernandez

Abstract

The main oral drug absorption barriers are fluid cell membranes and generally drugs are absorbed by a passive diffusion mechanism. Biopartitioning micellar chromatography (BMC) is a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 under adequate experimental conditions and can be useful to mimic the drug partitioning process in biological systems. In this paper the usefulness of BMC for predicting oral drug absorption in humans is demonstrated. A hyperbolic model has been obtained using the retention data of a heterogeneous set of 74 compounds, which shows predictive ability for drugs absorbed by passive diffusion. The model obtained in BMC is compared with those obtained using the well-known systems (Caco-2 and TC-7) that use intestinal epithelium cell lines. The use of BMC is simple, reproducible and can provide key information about the transport properties of new compounds during the drug discovery process.

References

Feb 17, 1995·Journal of Medicinal Chemistry·C PidgeonL Glunz
Apr 3, 1999·Journal of Pharmaceutical Sciences·V Pade, S Stavchansky
Aug 17, 1999·Journal of Medicinal Chemistry·C Quiñones-TorreloM J Medina-Hernández
Jun 23, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·J J Martínez-PlaM J Medina-Hernández

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Citations

Jan 31, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·C Quiñones-TorreloM J Medina-Hernández
Oct 11, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Y Martín-BioscaM J Medina-Hernández
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·L Escuder-GilabertM J Medina-Hernández
Jun 3, 2004·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Sándor Görög
Sep 2, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Gengliang YangYu Zhao
Dec 4, 2003·Biomedical Chromatography : BMC·J J Martínez-PlaM J Medina-Hernández
Dec 4, 2003·Biomedical Chromatography : BMC·Marina D RukhadzeNino Sh Sidamonidze
Oct 22, 2008·Biomedical Chromatography : BMC·L Escuder-GilabertM J Medina-Hernandez
May 4, 2011·Drug Testing and Analysis·H NoorizadehM Kohzadi
Jun 27, 2012·Journal of Separation Science·Juan José Fernández-NavarroMaría Celia García-Álvarez-Coque
Dec 1, 2004·Drug Discovery Today. Technologies·Thorsten Hartmann, Johannes Schmitt
Oct 6, 2004·Journal of Chromatography. a·J J Martínez-PlaM J Medina-Hernández
Jun 19, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·L Escuder-GilabertM J Medina-Hernández
Oct 3, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sumin WangZhiwei Li
Feb 1, 2006·Environmental Toxicology and Pharmacology·Ruth HylandHan van de Waterbeemd
Apr 17, 2016·Journal of Pharmaceutical and Biomedical Analysis·Klára L Valkó
Jun 5, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Yuri A Diaz FernandezJose M Fernandez Hechavarria
Oct 26, 2016·Journal of Pharmaceutical Sciences·Laura J WatersJohn C Mitchell
Apr 3, 2016·Biomedical Chromatography : BMC·Laura J WatersGareth M B Parkes
May 1, 2010·Expert Opinion on Drug Discovery·Raul NicoliDavy Guillarme
Jan 28, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vladimir DobričićJasmina Brborić
Jun 24, 2017·Expert Opinion on Drug Discovery·Fotios TsopelasAnna Tsantili-Kakoulidou
Oct 16, 2018·Journal of Pharmaceutical Sciences·Dina S ShokryMartin J Snowden

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