Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.)

Fitoterapia
Syed Haris OmarHassan K Obied

Abstract

The focus of this study was on inhibition of enzymes involved in the pathogenesis Alzheimer's disease (AD) including prime amyloid beta (Aβ) producing enzyme (β-secretase: BACE-1) and disease progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the catecholamine L-DOPA, by using olive biophenols. Here we report the strongest inhibition of BACE-1 from rutin (IC50: 3.8 nM) followed by verbascoside (IC50: 6.3 nM) and olive fruit extract (IC50: 18 ng), respectively. Olive biophenol, quercetin exhibited strongest enzyme inhibitory activity against tyrosinase (IC50: 10.73 μM), BChE (IC50: 19.08 μM), AChE (IC50: 55.44 μM), and HDAC (IC50: 105.1 μM) enzymes. Furthermore, olive biophenol verbascoside (IC50: 188.6 μM), and hydroxytyrosol extreme extract (IC50: 66.22 μg) were showed the highest levels of inhibition against the HDAC enzyme. Neuroprotective capacity against levodopa-induced toxicity in neuroblastoma (SH-SY5Y) cells of olive biophenols were assessed, where rutin indicated the highest neuroprotection (74%), followed by caffeic acid (73%), and extract hydroxytyrosol extreme (97%), respectively. To the best of our knowledge, this is the fi...Continue Reading

Citations

Jan 19, 2019·The Journal of Biological Chemistry·Hossein Mohammad-BeigiDaniel E Otzen
Jun 12, 2019·International Journal of Molecular Sciences·Syed Haris Omar
Aug 10, 2019·Chemistry & Biodiversity·Antonella SmeriglioMaria Paola Germanò
Feb 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giorgio D'AndreaFelice Tirone
Jan 2, 2019·International Journal of Molecular Sciences·Syed Haris OmarHassan K Obied
Jul 12, 2019·Frontiers in Aging Neuroscience·George A Edwards IiiInes Moreno-Gonzalez
Jul 28, 2020·Journal of Personalized Medicine·Syed Haris Omar, John Preddy
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
Mar 21, 2019·CNS & Neurological Disorders Drug Targets·Fahad Ali, Yasir Hasan Siddique
Dec 31, 2020·International Journal of Molecular Sciences·Katarzyna SocałaPiotr Wlaź
Mar 12, 2020·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Dominik SzwajgierJosef Zapp
Jan 7, 2022·Metabolomics : Official Journal of the Metabolomic Society·George E JaskiwCurtis J Donskey

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