Abstract
The focus of this study was on inhibition of enzymes involved in the pathogenesis Alzheimer's disease (AD) including prime amyloid beta (Aβ) producing enzyme (β-secretase: BACE-1) and disease progression enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), histone deacetylase (HDAC), and tyrosinase along with the catecholamine L-DOPA, by using olive biophenols. Here we report the strongest inhibition of BACE-1 from rutin (IC50: 3.8 nM) followed by verbascoside (IC50: 6.3 nM) and olive fruit extract (IC50: 18 ng), respectively. Olive biophenol, quercetin exhibited strongest enzyme inhibitory activity against tyrosinase (IC50: 10.73 μM), BChE (IC50: 19.08 μM), AChE (IC50: 55.44 μM), and HDAC (IC50: 105.1 μM) enzymes. Furthermore, olive biophenol verbascoside (IC50: 188.6 μM), and hydroxytyrosol extreme extract (IC50: 66.22 μg) were showed the highest levels of inhibition against the HDAC enzyme. Neuroprotective capacity against levodopa-induced toxicity in neuroblastoma (SH-SY5Y) cells of olive biophenols were assessed, where rutin indicated the highest neuroprotection (74%), followed by caffeic acid (73%), and extract hydroxytyrosol extreme (97%), respectively. To the best of our knowledge, this is the fi...Continue Reading
Citations
Jan 19, 2019·The Journal of Biological Chemistry·Hossein Mohammad-BeigiDaniel E Otzen
Jun 12, 2019·International Journal of Molecular Sciences·Syed Haris Omar
Aug 10, 2019·Chemistry & Biodiversity·Antonella SmeriglioMaria Paola Germanò
Feb 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giorgio D'AndreaFelice Tirone
Jan 2, 2019·International Journal of Molecular Sciences·Syed Haris OmarHassan K Obied
Jul 12, 2019·Frontiers in Aging Neuroscience·George A Edwards IiiInes Moreno-Gonzalez
Jul 28, 2020·Journal of Personalized Medicine·Syed Haris Omar, John Preddy
Oct 1, 2020·Biomedicines·Riaz AhmadMyeong Ok Kim
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
Mar 21, 2019·CNS & Neurological Disorders Drug Targets·Fahad Ali, Yasir Hasan Siddique
Dec 30, 2020·Journal of Pharmaceutical and Biomedical Analysis·Li-Hong YeJun Cao
Dec 31, 2020·International Journal of Molecular Sciences·Katarzyna SocałaPiotr Wlaź
Jan 28, 2021·Nutrients·Anamaria Jurcau
Feb 27, 2020·Bioorganic Chemistry·Aida IrajiNajmeh Edraki
Mar 25, 2021·Future Medicinal Chemistry·Tao LuYanfang Li
Apr 4, 2021·Molecular Biology Reports·Tolulope Olabode OshodiSolomon Umukoro
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·F Sezer Senol DenizIhsan Calis
May 14, 2021·European Journal of Medicinal Chemistry·João P S FerreiraVera L M Silva
Jul 3, 2021·Biology·Irshad Ul Haq Bhat, Rajeev Bhat
Mar 12, 2020·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Dominik SzwajgierJosef Zapp
Jan 7, 2022·Metabolomics : Official Journal of the Metabolomic Society·George E JaskiwCurtis J Donskey