May 12, 2006

Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity

International Journal of Neural Systems
Mathilde BadoualA Destexhe

Abstract

Spike-timing dependent plasticity (STDP) is a form of associative synaptic modification which depends on the respective timing of pre- and post-synaptic spikes. The biophysical mechanisms underlying this form of plasticity are currently not known. We present here a biophysical model which captures the characteristics of STDP, such as its frequency dependency, and the effects of spike pair or spike triplet interactions. We also make links with other well-known plasticity rules. A simplified phenomenological model is also derived, which should be useful for fast numerical simulation and analytical investigation of the impact of STDP at the network level.

  • References56
  • Citations19

Mentioned in this Paper

In Silico
Neurons
Neuronal Plasticity
Triplet, Centriole
Biophysics
Synapses
Mechanobiology
Nerve Impulses

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