Biophysical aspects and biological implications of the interaction of benzophenanthridine alkaloids with DNA

Biophysics Reviews
Motilal Maiti, Gopinatha Suresh Kumar

Abstract

Benzophenanthridine alkaloids represent a very interesting and significant group of natural products that exhibit a broad range of biological and pharmacological properties. Among this group of alkaloids, sanguinarine, nitidine, fagaronine, and chelerythrine have the potential to form molecular complexes with DNA structures and have attracted recent attention for their possible clinical and pharmacological utility. This review focuses on the interaction of these alkaloids with polymorphic DNA structures (B-form, Z-form, H(L)-form, and triple helical form) reported by several research groups employing various physical techniques such as spectrophotometry, spectrofluorimetry, circular dichroism, NMR spectroscopy, thermal melting, viscometry as well as thermodynamic analysis by isothermal titration calorimetry and differential scanning calorimetry to elucidate the mode and mechanism of action at the molecular level to determine the structure-activity relationship. DNA binding properties of these alkaloids are interpreted in relation to their biological activity.

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Citations

Jun 19, 2012·Journal of Biomolecular Structure & Dynamics·Maidul HossainGopinatha Suresh Kumar
Jan 16, 2010·Medicinal Research Reviews·Kakali Bhadra, Gopinatha Suresh Kumar
Apr 16, 2011·PloS One·Maidul HossainGopinatha Suresh Kumar
May 4, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Yizhong ShenYouqiu He
Sep 7, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Imee M A Del MundoGuliang Wang
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pengcheng WangHuaiji Zheng
Jul 30, 2014·Journal of Natural Products·Tayyab A MansoorMaria-José U Ferreira
Mar 19, 2014·The Journal of Physical Chemistry. B·Soumitra Hazra, Gopinatha Suresh Kumar

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