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Biophysical basis of cellular multi-specificity encoded in a model molecular switch

bioRxiv

Jan 6, 2020

Tina PericaTanja Kortemme

Abstract

Molecular switches are central to signal transduction in protein interaction networks. One switch protein can independently regulate distinct cellular processes, but the molecular mechanisms enabling this functional multi-specificity remain unclear. Here we integrate system-scale cellul...read more

Mentioned in this Paper

Protein-Protein Interaction
Cell Cycle Switching
Monomeric GTP-Binding Proteins
Allosteric Regulation
Guanosine Triphosphate Phosphohydrolases
Point Mutation
Signal Transduction
RAN
GSP1 protein, S cerevisiae
Cellular Process
39
1
Paper Details
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Biophysical basis of cellular multi-specificity encoded in a model molecular switch

bioRxiv

Jan 6, 2020

Tina PericaTanja Kortemme

DOI: 10.1101/2020.01.04.893909

Abstract

Molecular switches are central to signal transduction in protein interaction networks. One switch protein can independently regulate distinct cellular processes, but the molecular mechanisms enabling this functional multi-specificity remain unclear. Here we integrate system-scale cellul...read more

Mentioned in this Paper

Protein-Protein Interaction
Cell Cycle Switching
Monomeric GTP-Binding Proteins
Allosteric Regulation
Guanosine Triphosphate Phosphohydrolases
Point Mutation
Signal Transduction
RAN
GSP1 protein, S cerevisiae
Cellular Process
39
1

Similar Papers Found In These Feeds

BioRxiv Preprints

BioRxiv is the preprint server for biology, operated by Cold Spring Harbor Laboratory. Here are the latest biology preprint articles from bioRxiv.

BioHub - Researcher Network

The Chan-Zuckerberg Biohub aims to support the fundamental research and develop the technologies that will enable physicians to cure, prevent, or manage all diseases in our childrens' lifetimes. The CZ Biohub brings together researchers from UC Berkeley, Stanford, and UCSF. Find the latest research from the CZ Biohub researcher network here.

Related Papers

Biochemical Society Transactions

Small GTPases and cell cycle regulation

Biochemical Society TransactionsAugust 5, 2000
C J Marshall
Protein Science : a Publication of the Protein Society

A tale of two GTPases in cotranslational protein targeting

Protein Science : a Publication of the Protein SocietySeptember 8, 2011
Ishu SaraogiShu-Ou Shan
Paper Details
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