Biophysical basis of subthalamic local field potentials recorded from deep brain stimulation electrodes

Journal of Neurophysiology
Nicholas MalingCameron C McIntyre

Abstract

Clinical deep brain stimulation (DBS) technology is evolving to enable chronic recording of local field potentials (LFPs) that represent electrophysiological biomarkers of the underlying disease state. However, little is known about the biophysical basis of LFPs, or how the patient's unique brain anatomy and electrode placement impact the recordings. Therefore, we developed a patient-specific computational framework to analyze LFP recordings within a clinical DBS context. We selected a subject with Parkinson's disease implanted with a Medtronic Activa PC+S DBS system and reconstructed their subthalamic nucleus (STN) and DBS electrode location using medical imaging data. The patient-specific STN volume was populated with 235,280 multicompartment STN neuron models, providing a neuron density consistent with histological measurements. Each neuron received time-varying synaptic inputs and generated transmembrane currents that gave rise to the LFP signal recorded at DBS electrode contacts residing in a finite element volume conductor model. We then used the model to study the role of synchronous beta-band inputs to the STN neurons on the recorded power spectrum. Three bipolar pairs of simultaneous clinical LFP recordings were used i...Continue Reading

References

Jul 11, 2000·The Journal of Comparative Neurology·F SatoA Parent
Jan 13, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Julie-Christine Lévesque, André Parent
Aug 2, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Michael A Moffitt, Cameron C McIntyre
Sep 9, 2005·Journal of Neurophysiology·Andrew Gillies, David Willshaw
Sep 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jérôme BaufretonMark D Bevan
Feb 5, 2009·PloS One·Joshua MilsteinChristof Koch
Feb 10, 2009·Frontiers in Neuroinformatics·Michael L HinesEilif Muller
Apr 8, 2009·Biophysical Journal·Claude Bédard, Alain Destexhe
Jan 26, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Scott StanslaskiTimothy Denison
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Max C KeukenBirte U Forstmann
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shoichi A ShimamotoPhilip A Starr
Oct 19, 2013·Nature Reviews. Neuroscience·Gaute T EinevollStefano Panzeri
Oct 24, 2013·Current Opinion in Neurology·Ashwini OswalVladimir Litvak
Aug 28, 2014·Brain Stimulation·Cameron C McIntyreScott F Lempka
Sep 19, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew I YangKareem A Zaghloul
Sep 12, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Emma J QuinnHelen Brontë-Stewart
Nov 27, 2015·Neuropsychology Review·Zack Blumenfeld, Helen Brontë-Stewart
Jun 17, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole C SwannPhilip A Starr
Oct 7, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Dan ValskyZvi Israel
Nov 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Zack BlumenfeldHelen Brontë-Stewart
Feb 17, 2017·Journal of Neurophysiology·Odeya MarmorRenana Eitan
Mar 24, 2017·Brain : a Journal of Neurology·Gerd TinkhauserPeter Brown
Jun 10, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Anders Christian MeidahlPeter Brown
Nov 19, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Gerd TinkhauserMichael Schuepbach

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Citations

Sep 4, 2019·Nature Biotechnology·Hayriye CagnanPeter Brown
Sep 4, 2019·Nature Biotechnology·Shaun R Patel, Charles M Lieber
Aug 22, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Bernadette C M van WijkBirte U Forstmann
Dec 1, 2018·Bioelectronics in Medicine·Xiaoyu PengCristin G Welle
Apr 20, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M Sohail Noor, Cameron C McIntyre
Jun 7, 2021·Brain Structure & Function·Clayton S BinghamCameron C McIntyre

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Methods Mentioned

BETA
dissection

Software Mentioned

NEURON
Comsol
Python
Gnu
Activa

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