Biophysical chemistry of the ageing eye lens

Biophysics Reviews
Nicholas J Ray

Abstract

This review examines both recent and historical literature related to the biophysical chemistry of the proteins in the ageing eye, with a particular focus on cataract development. The lens is a vital component of the eye, acting as an optical focusing device to form clear images on the retina. The lens maintains the necessary high transparency and refractive index by expressing crystallin proteins in high concentration and eliminating all large cellular structures that may cause light scattering. This has the consequence of eliminating lens fibre cell metabolism and results in mature lens fibre cells having no mechanism for protein expression and a complete absence of protein recycling or turnover. As a result, the crystallins are some of the oldest proteins in the human body. Lack of protein repair or recycling means the lens tends to accumulate damage with age in the form of protein post-translational modifications. The crystallins can be subject to a wide range of age-related changes, including isomerisation, deamidation and racemisation. Many of these modification are highly correlated with cataract formation and represent a biochemical mechanism for age-related blindness.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V J StevensA Cerami
Jan 1, 1986·Annual Review of Biochemistry·S Lindquist
Jul 15, 1989·European Journal of Biochemistry·H J AartsJ G Schoenmakers
Jan 16, 1989·Biochemical and Biophysical Research Communications·S P Bhat, C N Nagineni
Dec 1, 1987·International Journal of Peptide and Protein Research·S Clarke
Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J Sebag
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M H Garner, A Spector
Apr 15, 1995·The Biochemical Journal·J B SmithP Russell
May 1, 1993·Forensic Science International : Synergy·T Solheim
Aug 26, 1998·Nature·K K KimS H Kim
Apr 27, 1999·Progress in Retinal and Eye Research·B K Derham, J J Harding
Apr 5, 2000·Progress in Retinal and Eye Research·P N Bishop
May 10, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·F J Giblin
Dec 21, 2000·Trends in Cell Biology·R R Kopito
Apr 20, 2001·Experimental Eye Research·L TakemotoD Boyle
Aug 25, 2001·Experimental Eye Research·O A BatemanC Slingsby
Mar 7, 2002·Experimental Eye Research·Steven Bassnett
Jun 18, 2002·Ageing Research Reviews·John J Harding
Dec 12, 2002·Biochemistry·Veniamin N LapkoJean B Smith
Feb 5, 2003·Experimental Eye Research·Joseph Horwitz
Apr 12, 2003·International Journal of Legal Medicine·S Ritz-TimmeM Collins
Jun 26, 2003·Experimental Eye Research·Ralph MichaelThomas J T P van den Berg
Aug 2, 2003·Progress in Retinal and Eye Research·Marjorie F Lou
Aug 22, 2003·Organic & Biomolecular Chemistry·Morio YashiroYuki Fujii
Aug 29, 2003·Cellular and Molecular Life Sciences : CMLS·K J Reissner, D W Aswad
Sep 6, 2003·Experimental Eye Research·O A BatemanC Slingsby
Oct 24, 2003·Protein Science : a Publication of the Protein Society·Rob L M Van MontfortChristine Slingsby
Mar 24, 2004·Seminars in Cell & Developmental Biology·Christopher M Dobson
Aug 11, 2004·Progress in Biophysics and Molecular Biology·Hans BloemendalAnnette Tardieu
Sep 29, 2004·Investigative Ophthalmology & Visual Science·Xiaohui WangDavid C Beebe
Feb 1, 2005·Biochimica Et Biophysica Acta·Earl R StadtmanRodney L Levine
Feb 22, 2005·Protein Science : a Publication of the Protein Society·Shannon L FlaughJonathan King
Feb 22, 2005·Protein Science : a Publication of the Protein Society·Joy G Ghosh, John I Clark
May 3, 2005·Experimental Eye Research·Roger J W Truscott
Oct 6, 2005·Nature Structural & Molecular Biology·Martin HaslbeckJohannes Buchner
Dec 7, 2005·Progress in Retinal and Eye Research·Alice BanhJacob G Sivak
Jun 8, 2006·Annual Review of Biochemistry·Fabrizio Chiti, Christopher M Dobson
Jul 15, 2006·BMJ : British Medical Journal·David Allen, Abhay Vasavada

❮ Previous
Next ❯

Citations

Nov 27, 2019·Current Opinion in Ophthalmology·Rebecca R Lian, Natalie A Afshari
Jun 13, 2019·Scientific Reports·Damian M DaszynskiPeter F Kador
Jun 27, 2019·The Journal of Biological Chemistry·Rebeccah A WarmackSteven G Clarke
Nov 2, 2019·Experimental Eye Research·Jack V Greiner, Thomas Glonek
Jun 25, 2021·Antioxidants & Redox Signaling·Peter F Kador, Richard Salvi
Jun 14, 2021·Experimental Eye Research·Adam P FarandaMelinda K Duncan
Dec 11, 2020·The Journal of Physical Chemistry. B·Khandekar Jishan Bari, Shrikant Sharma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Biochimica Et Biophysica Acta
K Krishna Sharma, Puttur Santhoshkumar
Experimental Eye Research
Larry Takemoto, Christopher Sorensen
© 2022 Meta ULC. All rights reserved