Bioprospecting Deep-Sea Actinobacteria for Novel Anti-infective Natural Products

Frontiers in Microbiology
Dongbo XuGuojun Wang

Abstract

The global prevalence of drug resistance has created an urgent need for the discovery of novel anti-infective drugs. The major source of antibiotics in current clinical practice is terrestrial actinobacteria; the less-exploited deep-sea actinobacteria may serve as an unprecedented source of novel natural products. In this study, we evaluated 50 actinobacteria strains derived from diverse deep water sponges and environmental niches for their anti-microbial activities against a panel of pathogens including Candida albicans, Clostridium difficile, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), and Pseudomonas aeruginosa. More than half of the tested strains (27) were identified as active in at least one assay. The rare earth salt lanthanum chloride (LaCl3) was shown to be as an effective elicitor. Among the 27 strains, the anti-microbial activity of 15 were induced or enhanced by the addition of LaCl3. This part of study focused on one strain R818, in which potent antifungal activity was induced by the addition of LaCl3. We found that the LaCl3-activated metabolites in R818 are likely antimycin-type compounds. One of them, compound 1, has been purified. Spectroscopic analyses including HR-MS and 1D NMR indicate...Continue Reading

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Jun 10, 2019·Journal of Industrial Microbiology & Biotechnology·Hailey A TommAvena C Ross
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Nov 19, 2019·Current Opinion in Microbiology·Olga Genilloud
Jul 3, 2021·Antibiotics·Martha Lok-Yung HuiLearn-Han Lee

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Datasets Mentioned

BETA
KC747479.1

Methods Mentioned

BETA
NMR

Software Mentioned

BLAST
GraphPad
GraphPad PRISM

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