Biopsy-diagnosed antibody-mediated rejection based on the proposed International Society for Heart and Lung Transplantation working formulation is associated with adverse cardiovascular outcomes after pediatric heart transplant

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Melanie D EverittAbdallah G Kfoury

Abstract

There is greater awareness of the pathologic features and clinical implications of antibody-mediated rejection (AMR) after heart transplantation (HT). Yet, compared with adults, the lack of routine surveillance for AMR has limited the growth of evidence in the pediatric population. Herein, we compared outcomes of pediatric HT recipients with and without AMR. All recipients ≤18 years of age with at least 1 endomyocardial biopsy (EMB) between 1988 and 2009 were included in this study. Assessment for AMR was routine. AMR severity was assigned retrospectively using the proposed 2011 ISHLT grading schema for pathologic AMR (pAMR). Outcome comparisons were made between patients with histologic and immunopathologic evidence for AMR (pAMR 2), those with severe AMR (pAMR 3), and those without evidence of AMR (pAMR 0) or without both histologic and immunopathologic findings (pAMR 1). Among 1,406 EMBs, pAMR 2 or higher was present in 258 (18%), occurring in 45 of 76 (59%) patients. Of the 17 episodes of pAMR 3 in 9 patients, 6 (35%) were sub-clinical. Mortality was not different between groups. Patients with at least 1 pAMR 3 episode had lower freedom from cardiovascular (CV) mortality or cardiac allograft vasculopathy within 5 years of H...Continue Reading

References

Jun 14, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Elfriede PahlUNKNOWN Pediatric Heart Transplant Study
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Susan StewartMargaret E Billingham
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M Elizabeth H HammondUNKNOWN Utah Transplant Affiliated Hospitals (UTAH) Cardiac Transplant Program
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A KobashigawaR D Gordon
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A KobashigawaUNKNOWN Study Investigators
Aug 8, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ramzi T NicolasCharles E Canter
Nov 14, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Abdallah G KfouryM Elizabeth H Hammond
Jan 30, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tim W CasarezDaniel S Levi
Jan 13, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Abdallah G KfouryM Elizabeth H Hammond
May 7, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Grace W WuAbbas Ardehali
Jul 28, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Abdallah G KfouryDale G Renlund
Mar 9, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jeffrey G GossettUNKNOWN Pediatric Heart Transplant Study Investigators
Jul 10, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Dilip S NathThalachallour Mohanakumar
Jul 14, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mandeep R MehraPatricia A Uber
Sep 22, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Monica P ReveloAbdallah G Kfoury
Sep 28, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Richard KirkMarshall I Hertz
Oct 27, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Melanie D EverittUNKNOWN Pediatric Heart Transplant Study Investigators
Jan 12, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J D SmithM L Rose
Feb 9, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon KobashigawaUNKNOWN Consensus Conference Participants
May 11, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gerald J BerryMandeep R Mehra
Jan 1, 1993·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·E H HammondR L Yowell

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Citations

Nov 10, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Paul MohacsiClaudia Boesch
Sep 3, 2013·Current Opinion in Pediatrics·Debra A Dodd
Jun 16, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jill SavlaJoseph W Rossano
Aug 17, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ryan J ButtsAndrew M Atz
Nov 2, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Adam L WareMelanie D Everitt
Jan 28, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Keyur B ShahMandeep R Mehra
Apr 9, 2013·The Annals of Thoracic Surgery·Bari MurtuzaMartin Kostolny
Mar 13, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·M Elizabeth H HammondAbdallah G Kfoury
Aug 26, 2014·Pathology International·Hatsue Ishibashi-UedaTakeshi Nakatani
Sep 13, 2015·JACC. Heart Failure·Scott R Auerbach
Jul 15, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jon A Kobashigawa
May 20, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kenneth R KnechtElizabeth A Frazier
Jul 20, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Philip T ThrushWilliam T Mahle
Dec 6, 2011·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ornella LeoneGayle L Winters
Oct 25, 2016·Journal of Biomedical Science·Nicholas E Burgis
Feb 18, 2017·Current Opinion in Cardiology·M Elizabeth H Hammond, Abdallah G Kfoury
Feb 18, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Mandy LangstraatLuciano Potena
Oct 11, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Raheel RizwanDavid L Morales
Jun 21, 2014·The Journal of Nutrition, Health & Aging·S SharmaL N Kolonel
May 14, 2020·Expert Opinion on Pharmacotherapy·Giosafat SpitaleriLuciano Potena
Feb 6, 2018·Journal of Cardiac Surgery·Ziyad M BinsalamahCarlos M Mery
Nov 26, 2020·Clinical and Experimental Pediatrics·Young Hwue Kim
Aug 24, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Benjamin S MantellEmmanuel Zorn

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