Biopsy in a series of 130 pediatric diffuse intrinsic Pontine gliomas

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Stephanie PugetChristian Sainte-Rose

Abstract

Diffuse intrinsic pontine glioma (DIPG) is the most severe pediatric solid tumor, with no significant improvement in the past 50 years. Possible reasons for failure to make therapeutic progress include poor understanding of the underlying molecular biology due to lack of tumor material. We performed a prospective analysis of children with typical appearance of DIPG who had a stereotactic biopsy in our unit since 2002. Technical approach, complications, histopathological results, and samples processing are exposed. The literature on this subject is discussed. Reviewing our own 130 cases of DIPG biopsies and previous published data, these procedures appear to have a diagnostic yield and morbidity rates similar to those reported for other brain locations (3.9 % of transient morbidity in our series). In addition, the quality and the quantity of the material obtained allow to (1) confirm the diagnosis, (2) reveal that WHO grading was useless to predict outcome, and (3) perform an extended molecular screen, including biomarkers study and the development of preclinical models. Recent studies reveal that DIPG may comprise more than one biological entity and a unique oncogenesis involving mutations never described in other types of canc...Continue Reading

References

Dec 1, 1988·Journal of Neuro-oncology·F Epstein, J H Wisoff
Dec 1, 1986·Journal of Neurosurgery·A R StroinkR P Humphreys
Jan 1, 1986·Journal of Neurosurgery·F Epstein, E L McCleary
Dec 8, 1998·Acta neurochirurgica·J Valdés-GorcíaE Paredes-Díaz
May 7, 2003·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·F Chico-Ponce de LeónA DeMontesinos-Sampedro
Jan 27, 2004·Stereotactic and Functional Neurosurgery·Uzma Samadani, Kevin D Judy
Jan 31, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·E J St GeorgeS Sgouros
Mar 2, 2006·Journal of Neurosurgery·David W PincusAmy Smith
Jul 21, 2007·Journal of Neurosurgery·Demitre Serletis, Mark Bernstein
Jul 25, 2007·Journal of Neurosurgery·Thomas RoujeauChristian Sainte-Rose
Nov 19, 2008·British Journal of Neurosurgery·R Wilkinson, J Harris
Nov 19, 2008·British Journal of Neurosurgery·P A LeachI D Kamaly-Asl
Feb 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam ZarghooniCynthia Hawkins
Jun 24, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dorine A BaxChris Jones
Sep 24, 2010·Stereotactic and Functional Neurosurgery·Vedantam Rajshekhar, Ranjith K Moorthy
Oct 27, 2010·Neuro-oncology·Birgit GeoergerUNKNOWN ITCC (Innovative Therapies for Children with Cancer) European Consortium
Feb 8, 2011·PloS One·Cécile ThirantMarie-Pierre Junier
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michelle MonjePhilip A Beachy
May 3, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Soumen KhatuaJohn R W Kestle
Jul 5, 2011·Journal of Neurosurgery. Pediatrics·Todd C HankinsonMichael H Handler
Jul 19, 2011·Cancer Treatment Reviews·M H A JansenG J L Kaspers
Sep 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara S PaughSuzanne J Baker
Nov 9, 2011·Neuro-oncology·Katherine E WarrenPaul S Meltzer
Dec 23, 2011·Pediatric Blood & Cancer·Jacques GrillMark W Kieran
Jan 31, 2012·Nature Genetics·Gang WuUNKNOWN St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project
Jan 31, 2012·Stereotactic and Functional Neurosurgery·Marcos DellarettiSerge Blond
Aug 24, 2013·Cancer Research·Barbara S PaughSuzanne J Baker
Apr 8, 2014·Nature Genetics·Adam M FontebassoMark W Kieran
Apr 8, 2014·Nature Genetics·Kathryn R TaylorJacques Grill
May 6, 2014·Journal of Neuro-oncology·Nathan J Robison, Mark W Kieran
Sep 30, 2014·Pediatric Blood & Cancer·Zhihong J WangSandeep Sood

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Citations

Jul 6, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Z Gokce-SamarD Frappaz
Jul 17, 2016·World Neurosurgery·Beuriat Pierre-AurélienFrappaz Didier
Mar 28, 2017·World Neurosurgery·Johanna Quick-WellerGerhard Marquardt
Sep 8, 2018·Journal of Neurosurgery. Pediatrics·Maria-Jesus Lobon-IglesiasAndres Morales La Madrid
Feb 17, 2019·Journal of Neurosurgery. Pediatrics·Constanze Buus-GehrigKonrad Bochennek
Mar 13, 2019·International Journal of Cancer. Journal International Du Cancer·Sabine MuellerAdam C Resnick
Oct 25, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ramiro J Del RioR Jaimovich
Jul 28, 2019·Brain Pathology·Charlotte DufourFlorence Renaud
Jul 11, 2019·Current Treatment Options in Neurology·Nicholas A Vitanza, Michelle Monje
Apr 14, 2020·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Adrian LevineChristopher Dunham
May 2, 2020·Médecine sciences : M/S·Virginie Menez, Marie-Anne Debily
Oct 2, 2019·Journal of Neuro-oncology·Jared T AhrendsenSanda Alexandrescu
Feb 25, 2017·Pediatric Blood & Cancer·Alicia Castañeda HerediaAndres Morales La Madrid
Mar 3, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Andres Morales La MadridEric Bouffet
Jun 30, 2018·Acta Neuropathologica Communications·Grant L LinMichelle Monje
Dec 6, 2019·Cancer Metastasis Reviews·Wafaa M RashedMohamed Saad Zaghloul
Jan 7, 2020·Asian Journal of Neurosurgery·Altaf Ali LaghariDaniyal Aziz Khan
Oct 4, 2020·Cancers·Henriette PedersenPetra Hamerlik
Sep 11, 2019·Journal of Neuro-oncology·Laflamme PhilippeLarouche Valérie
Jun 17, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Victor M LuDavid J Daniels
Dec 15, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Barbara Albuquerque MoraisBernardo A Monaco
Mar 22, 2020·Acta Neuropathologica Communications·Drew PrattSriram Venneti
Aug 10, 2017·Frontiers in Pharmacology·Wenyong LongQing Liu
Oct 27, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sharon Y Y LowWan Tew Seow
Apr 13, 2017·Frontiers in Oncology·Danielle H LapinDavid S Ziegler
Apr 25, 2020·Acta Neuropathologica Communications·Jason ChiangChristopher L Tinkle
Sep 30, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ralph E NavarroEveline Teresa Hidalgo

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