Abstract
Most patients, even those who have received a liver transplant, achieve a sustained virologic response (SVR) to therapy for hepatitis C virus (HCV) infection. Little is known about the histologic features of liver biopsy specimens collected after SVR, particularly in patients who have received a liver transplant. We aimed to better characterize the histologic features of allograft liver biopsy specimens from patients who achieved SVR to anti-HCV therapy after liver transplantation. We performed a retrospective analysis of 170 allograft liver biopsy specimens from 36 patients who received a liver transplant for chronic HCV infection, had recurrent HCV infection after transplantation, and subsequently achieved SVR (collected from 1999 through 2015 at 4 medical centers). SVR was defined as an undetectable serum HCV RNA level 24 weeks after completion of HCV treatment. A total of 65 biopsy specimens were post-SVR (at least 1 post-SVR from each patient; some biopsy specimens were collected at later time points from a subset of patients). We performed polymerase chain reaction analysis for HCV RNA on a subset of the biopsy specimens (28 collected before SVR and 32 after SVR). Of the 65 post-SVR biopsy specimens, 45 (69%) had histolog...Continue Reading
References
Dec 1, 1995·The American Journal of Surgical Pathology·K P Batts, J Ludwig
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R B GuerreroD H Persing
Jan 27, 2004·Transplantation·Hector Rodriguez-LunaHugo E Vargas
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Aug 19, 2005·Nature·Jordan J Feld, Jay H Hoofnagle
May 24, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Wing-Kin SynJames M Neuberger
Dec 2, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Aya Miyagawa-HayashinoToshiaki Manabe
Dec 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sarah L GeorgeAdrian M Di Bisceglie
Jan 13, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W R KimB L Kasiske
Citations
Sep 30, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ezequiel MauroMiquel Navasa
Dec 6, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khurram BariShimul A Shah
Dec 14, 2017·Histopathology·Juan PutraM Isabel Fiel
Jul 30, 2019·PLoS Pathogens·Erin Heather DoyleAndrea D Branch
Aug 24, 2019·Clinical Transplantation·Adam C WintersThomas D Schiano
Oct 28, 2019·Digestive Diseases and Sciences·Rui HuangLai Wei
Jun 11, 2020·Current Opinion in Organ Transplantation·Katya Prakash, Saima Aslam
Mar 14, 2020·Sensors·Sultan AlmotairiMohammed A-M Salem
Nov 6, 2018·United European Gastroenterology Journal·Masaru EnomotoNorifumi Kawada
Jan 3, 2020·Digestive Diseases and Sciences·Masaru Enomoto, Norifumi Kawada
Nov 10, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ethan M WeinbergK Rajender Reddy
Feb 16, 2021·World Journal of Gastroenterology : WJG·Rui HuangLai Wei
Aug 19, 2020·Archives of Pathology & Laboratory Medicine·Romulo CelliDhanpat Jain
Mar 11, 2021·Clinical Transplantation·Satheesh P NairJames D Eason
Mar 1, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Amare AregayHeiner Wedemeyer
Jul 17, 2021·Scientific Reports·Omar A SaldarriagaHeather L Stevenson
Sep 10, 2021·Virchows Archiv : an International Journal of Pathology·Vedha SanghiDaniela S Allende