Biopsy Specimens From Allograft Liver Contain Histologic Features of Hepatitis C Virus Infection After Virus Eradication

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Emma WhitcombMaria Westerhoff

Abstract

Most patients, even those who have received a liver transplant, achieve a sustained virologic response (SVR) to therapy for hepatitis C virus (HCV) infection. Little is known about the histologic features of liver biopsy specimens collected after SVR, particularly in patients who have received a liver transplant. We aimed to better characterize the histologic features of allograft liver biopsy specimens from patients who achieved SVR to anti-HCV therapy after liver transplantation. We performed a retrospective analysis of 170 allograft liver biopsy specimens from 36 patients who received a liver transplant for chronic HCV infection, had recurrent HCV infection after transplantation, and subsequently achieved SVR (collected from 1999 through 2015 at 4 medical centers). SVR was defined as an undetectable serum HCV RNA level 24 weeks after completion of HCV treatment. A total of 65 biopsy specimens were post-SVR (at least 1 post-SVR from each patient; some biopsy specimens were collected at later time points from a subset of patients). We performed polymerase chain reaction analysis for HCV RNA on a subset of the biopsy specimens (28 collected before SVR and 32 after SVR). Of the 65 post-SVR biopsy specimens, 45 (69%) had histolog...Continue Reading

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Citations

Sep 30, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ezequiel MauroMiquel Navasa
Dec 6, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Khurram BariShimul A Shah
Jun 11, 2020·Current Opinion in Organ Transplantation·Katya Prakash, Saima Aslam
Mar 14, 2020·Sensors·Sultan AlmotairiMohammed A-M Salem
Jan 3, 2020·Digestive Diseases and Sciences·Masaru Enomoto, Norifumi Kawada
Nov 10, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ethan M WeinbergK Rajender Reddy
Mar 1, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Amare AregayHeiner Wedemeyer
Sep 10, 2021·Virchows Archiv : an International Journal of Pathology·Vedha SanghiDaniela S Allende

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