Biopterin cofactor and monoamine-synthesizing monooxygenases

Neurochemistry International
T Nagatsu


The activities of three pterin-requiring monooxygenases, phenylalanine hydroxylase, tyrosine hydroxylase and tryptophan hydroxylase, are regulated by the level of the pterin cofactor, (6R)- l -erythro- tetrahydrobiopterin , which is synthesized from guanosine triphosphate (GTP). Since tyrosine hydroxylase or tryptophan hydroxylase is the rate-limiting enzyme for the biosynthesis of catecholamines (dopamine, norepinephrine and epinephrine) or serotonin in monoaminergic neurons, biosynthesis of tetrahydrobiopterin from GTP may also regulate the tissue level of monoamine transmitters. Recent evidences indicate that biosynthesis of tetrahydrobiopterin and that of biogenic monoamines may be regulated each other.


Nov 1, 1975·Biochemical Pharmacology·Y NumataS Matsuura
Jan 1, 1976·Life Sciences·D H Park, M Goldstein
Jan 11, 1977·Biochimica Et Biophysica Acta·Y NumataS Matsuura
Mar 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·T NagatsuM Sano
Mar 14, 1978·Biochimica Et Biophysica Acta·T NagatsuM Akino
Mar 1, 1978·Annals of Neurology·I J ButlerS Kaufman
May 30, 1978·Biochemical and Biophysical Research Communications·T Yamauchi, H Fujisawa
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T H JohD J Reis
May 1, 1979·Journal of Neurochemistry·R A LevineW Lovenberg
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·W LovenbergI Hanbauer
Apr 16, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·H C CurtiusH Schmidt
Sep 28, 1978·The New England Journal of Medicine·S KaufmanS Pueschel
Oct 1, 1975·Journal of Neurochemistry·M B YoudimS Bourgoin
Oct 16, 1975·The New England Journal of Medicine·S KaufmanA Krumholz
Oct 24, 1975·Brain Research·M J BrownsteinJ S Kizer
Jul 12, 1974·Science·R J WurtmanJ D Fernstrom
Jul 15, 1972·Biochemical Pharmacology·T NagatsuT Sugimoto
Oct 8, 1974·Biochemical and Biophysical Research Communications·T NukiwaA Ichiyama
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J M MusacchioC A McQueen
Nov 1, 1967·Analytical Biochemistry·G GuroffA Abramowitz
May 1, 1969·Biochemical Pharmacology·E JequierA Sjoerdsma
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P R VullietN Weiner
Mar 14, 1980·Biochimica Et Biophysica Acta·T KatoS Matsuura
Feb 5, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·T NagatsuH Narabayashi
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M M Abou-Donia, O H Viveros
May 29, 1981·Biochemical and Biophysical Research Communications·T Yamauchi, H Fujisawa
Sep 15, 1981·Biochimica Et Biophysica Acta·K OkaT Nagatsu
Feb 1, 1982·European Journal of Biochemistry·S Okuno, H Fujisawa
Dec 1, 1981·Journal of Neurochemistry·A J Mandell, P V Russo
Aug 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·A C WilliamsD B Calne
Mar 15, 1982·Biochemical and Biophysical Research Communications·S KatohS Yamada
Feb 1, 1982·European Journal of Biochemistry·H Nakata, H Fujisawa

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Jan 1, 1990·Journal of Neural Transmission. General Section·Y HirataT Nagatsu
Jan 1, 1988·The International Journal of Biochemistry·M Sawada, T Nagatsu
Jan 1, 1986·Neurochemistry International·A TogariT Nagatsu
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·S N Young, A M Ghadirian
Feb 19, 2002·Expert Opinion on Biological Therapy·Hoang N Le, David M Frim
Jan 5, 2001·Expert Opinion on Investigational Drugs·D M Frim, U J Kang
Jun 3, 2008·Journal of Neurochemistry·Sarah L GordonPhillip W Dickson
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