PMID: 12752202May 20, 2003Paper

Bioreabsorbable polymer scaffold as temporary meniscal prosthesis

Artificial Organs
Ana Paula Testa PezzinEliana Aparecida de Rezende Duek

Abstract

Menisci have an important role in load bearing, shock absorption, knee joint stability, and joint lubrication. Meniscal lesions and meniscectomy are followed by osteoarthritis in a high percentage of patients. At present, there is no ideal prosthesis for meniscal substitution. In this work, a bioreabsorbable polymer scaffold made of poly(L-lactic acid) (PLLA) and poly(p-dioxanone) (PPD) blend was developed to be used as a temporary meniscal prosthesis to stimulate the formation of an in situ meniscal replication while the scaffold is reabsorbed by the organism. Total meniscectomy of medial meniscus and arthrotomy was made in both back knees of 34 adult New Zealand white rabbits by medial parapatellar incision. The scaffolds were sutured in one of the knees, and other was used as a control. A meniscal replica was developed, suggesting that this material has great potential to be used as a meniscal prosthesis, especially because the new meniscus promoted a significant protection of cartilage, and cartilage degeneration in the control condyles was observed.

Citations

Nov 18, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Turgay EfeThomas J Heyse
Jul 16, 2008·Journal of Materials Science. Materials in Medicine·Michelle DiasM Isabel Felisberti
Jul 4, 2012·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Suzanne A MaherRussell F Warren
Dec 1, 2006·Sports Medicine and Arthroscopy Review·Gwendolyn M Hoben, Kyriacos A Athanasiou
Apr 16, 2004·Artificial Organs·Paul S Malchesky
Mar 27, 2009·Journal of Biomedical Materials Research. Part a·Robert H BrophySuzanne A Maher
Sep 14, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jahid HasanEileen Ingham
Jan 31, 2014·Biomaterials·Jan J RongenPieter Buma
Apr 18, 2013·BioResearch Open Access·Andrea Rodrigues EspositoEliana Aparecida de Rezende Duek
Jan 1, 2016·Journal of Biomechanical Engineering·Emily H LakesKyle D Allen
Jul 15, 2015·The Open Orthopaedics Journal·Berardo Di MatteoMaurilio Marcacci
Apr 18, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Davide RealeGiuseppe Filardo
Sep 28, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Davide RealeStefano Zaffagnini

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