Bioreactor Development for Lung Tissue Engineering

Current Transplantation Reports
Angela Panoskaltsis-Mortari

Abstract

Much recent interest in lung bioengineering by pulmonary investigators, industry and the organ transplant field has seen a rapid growth of bioreactor development ranging from the microfluidic scale to the human-sized whole lung systems. A comprehension of the findings from these models is needed to provide the basis for further bioreactor development. The goal was to comprehensively review the current state of bioreactor development for the lung. A search using PubMed was done for published, peer-reviewed papers using the keywords "lung" AND "bioreactor" or "bioengineering" or "tissue engineering" or "ex vivo perfusion". Many new bioreactors ranging from the microfluidic scale to the human-sized whole lung systems have been developed by both academic and commercial entities. Microfluidic, lung-mimic and lung slice cultures have the advantages of cost-efficiency and high throughput analyses ideal for pharmaceutical and toxicity studies. Perfused/ventilated rodent whole lung systems can be adapted for mid-throughput studies of lung stem/progenitor cell development, cell behavior, understanding and treating lung injury and for preliminary work that can be translated to human lung bioengineering. Human-sized ex vivo whole lung bior...Continue Reading

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Citations

Jun 16, 2018·The European Respiratory Journal·Martina M De SantisDarcy E Wagner
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Feb 26, 2021·Biotechnology and Bioengineering·Seyed Hossein MahfouziSeyed Hamid Safiabadi Tali

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