Bioreducible Fluorinated Peptide Dendrimers Capable of Circumventing Various Physiological Barriers for Highly Efficient and Safe Gene Delivery

ACS Applied Materials & Interfaces
Xiaojun CaiZhongwei Gu

Abstract

Polymeric vectors have shown great promise in the development of safe and efficient gene delivery systems; however, only a few have been developed in clinical settings due to poor transport across multiple physiological barriers. To address this issue and promote clinical translocation of polymeric vectors, a new type of polymeric vector, bioreducible fluorinated peptide dendrimers (BFPDs), was designed and synthesized by reversible cross-linking of fluorinated low generation peptide dendrimers. Through masterly integration all of the features of reversible cross-linking, fluorination, and polyhedral oligomeric silsesquioxane (POSS) core-based peptide dendrimers, this novel vector exhibited lots of unique features, including (i) inactive surface to resist protein interactions; (ii) virus-mimicking surface topography to augment cellular uptake; (iii) fluorination-mediated efficient cellular uptake, endosome escape, cytoplasm trafficking, and nuclear entry, and (iv) disulfide-cleavage-mediated polyplex disassembly and DNA release that allows efficient DNA transcription. Noteworthy, all of these features are functionally important and can synergistically facilitate DNA transport from solution to the nucleus. As a consequences, BFP...Continue Reading

References

Jan 14, 2000·Nature Biotechnology·D Luo, W M Saltzman
Mar 20, 2003·Journal of the American Chemical Society·Yasuhiro AoyamaTakuro Niidome
Mar 11, 2004·The Journal of Investigative Dermatology·Shariff DunlapRhonda M Alani
Dec 23, 2004·Journal of Pharmaceutical Sciences·Henry K BayeleAlexander T Florence
Mar 11, 2005·Advanced Drug Delivery Reviews·Ram I Mahato
May 21, 2005·The Journal of Gene Medicine·Miriam BreunigAchim Goepferich
Nov 29, 2005·Advanced Drug Delivery Reviews·Christine DufèsAndreas G Schätzlein
Dec 8, 2005·Nature Biotechnology·Cameron C LeeFrancis C Szoka
Jun 2, 2006·Nature Materials·David Putnam
Feb 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael NeuThomas Kissel
Aug 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Miriam BreunigAchim Goepferich
Jul 22, 2008·The Journal of Gene Medicine·Nicole M MooreShelly E Sakiyama-Elbert
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stephanie E A GrattonJoseph M DeSimone
Dec 23, 2008·Chemical Reviews·Rakesh Kumar TekadeNarendra Kumar Jain
Nov 17, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amir K VarkouhiHidde J Haisma
Jul 13, 2009·Biomacromolecules·Jon CallahanJindřich Kopeček
Jul 30, 2011·International Journal of Pharmaceutics·Tao WangVladimir P Torchilin
Sep 20, 2011·Biomaterials·Benjamin K K TeoEvelyn K F Yim
Dec 6, 2011·Nature Materials·Jiangbing ZhouW Mark Saltzman
Dec 1, 2010·Nano Today·Gang LiuXiaoyuan Chen
Apr 18, 2012·Macromolecular Bioscience·Remant Bahadur K CPeisheng Xu
May 2, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hye Yeong NamDavid A Bull
Oct 12, 2012·Journal of the American Chemical Society·Hongmei LiuYiyun Cheng
Oct 17, 2012·Biotechnology Advances·Shuohao Huang, Masamichi Kamihira
Aug 16, 2013·Advanced Materials·Yuting NiuChengzhong Yu
Apr 9, 2014·Biomaterials·Hongmei LiuYiyun Cheng
Apr 24, 2014·ACS Nano·Sangmin LeeKwangmeyung Kim
May 9, 2014·Advanced Healthcare Materials·Xiaojun CaiDonglu Shi
Jul 16, 2014·Nature Reviews. Genetics·Hao YinDaniel G Anderson
Oct 6, 2014·European Journal of Medicinal Chemistry·Chun-Yan LiXiao-Qi Yu
Nov 11, 2014·Molecular Pharmaceutics·Luís NovoWim E Hennink

❮ Previous
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Citations

Sep 25, 2016·Acta Biomaterialia·Mingming Wang, Yiyun Cheng
Nov 17, 2017·Nature Communications·Monica CarrilWolfgang J Parak
Oct 3, 2018·Therapeutic Delivery·Priya Sahadevan Syamala, Rekha Mannemcherril Ramesan
Jan 13, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mian WangHaijie Yang
Jul 6, 2019·Journal of Biomedical Materials Research. Part a·Gyeong Jin Lee, Tae-Il Kim
Feb 8, 2020·International Journal of Molecular Sciences·Carlos Sanchez-Cano, Mónica Carril
Sep 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Khan MuhammadYakai Feng
Jun 9, 2020·Drug Delivery and Translational Research·Lian XueDaniel J Siegwart
Nov 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Echuan TanYiyun Cheng
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shabnam TarvirdipourCornelia G Palivan
Feb 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hong LiangYu Nie
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qiaoping ZhangYakai Feng
Jan 23, 2021·Pharmaceutics·Haneen DaralnakhlaC I Edvard Smith
Oct 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara Maslanka FigueroaAchim Goepferich
Jan 28, 2019·Acta Biomaterialia·Shichao ZhangBingyun Li
Mar 8, 2020·Colloids and Surfaces. B, Biointerfaces·Maximiliano L AgazziOmar Azzaroni
Mar 10, 2021·Chemical Society Reviews·Jia Lv, Yiyun Cheng
Mar 13, 2021·ACS Applied Materials & Interfaces·Juan Manuel ArangoMónica Carril
Jan 18, 2018·Bioconjugate Chemistry·Saba AlapourFernando Albericio
Nov 23, 2018·ACS Applied Materials & Interfaces·Jiajia XiangYouqing Shen
Oct 4, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yun-Dan SunFu-Gen Wu
Feb 7, 2018·Journal of the American Chemical Society·Ya-Xuan ZhuFu-Gen Wu
Sep 27, 2019·Chemical Reviews·Rachit SapraV Haridas
Aug 16, 2019·Life Sciences·Fatemeh Sadat Tabatabaei MirakabadJavad Ranjbari

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